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Substance Name: Ebselen [INN]
RN: 60940-34-3
UNII: 40X2P7DPGH
InChIKey: DYEFUKCXAQOFHX-UHFFFAOYSA-N

Molecular Formula

  • C13-H9-N-O-Se

Molecular Weight

  • 274.18
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Antioxidants
  • Antirheumatic Agents
  • Central Nervous System Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Gastrointestinal Agents
  • Neuroprotective Agents
  • Peripheral Nervous System Agents
  • Protective Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Ebselen
  • Ebselen [INN]

Synonyms

  • 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
  • CCRIS 3714
  • Ebselen
  • Ebselene
  • Ebselene [French]
  • Ebseleno
  • Ebseleno [Spanish]
  • Ebselenum
  • Ebselenum [Latin]
  • NSC 639762
  • PZ 51
  • SPI-1005
  • UNII-40X2P7DPGH

Systematic Names

  • 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-
  • 2-Phenyl-1,2-benzisoselenazolin-3-one
  • Ebselen

Registry Numbers

CAS Registry Number

  • 60940-34-3

FDA UNII

  • 40X2P7DPGH

System Generated Number

  • 0060940343

Structure Descriptors

InChI

1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

InChIKey

DYEFUKCXAQOFHX-UHFFFAOYSA-N

Smiles

n1(c2ccccc2)c(c2ccccc2[se]1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
pig LD oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD oral > 4600mg/kg (4600mg/kg)   European Patent Application. Vol. #0044971,