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Substance Name: Acepromazine [INN:BAN]
RN: 61-00-7
UNII: 54EJ303F0R
InChIKey: NOSIYYJFMPDDSA-UHFFFAOYSA-N

Note

  • A phenothiazine that is used in the treatment of PSYCHOSES.

Molecular Formula

  • C19-H22-N2-O-S

Molecular Weight

  • 326.4618
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents

Names and Synonyms

Results Name

  • Acepromazine [INN:BAN]

Name of Substance

  • Acepromazine
  • Acepromazine [INN:BAN]

MeSH Heading

  • Acepromazine

Synonyms

  • 1-(10-(3-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone
  • 10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone
  • 10-(3-Dimethylaminopropyl)phenothiazine-3-ethylone
  • 1522 CB
  • 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine
  • Acepromazina
  • Acepromazina [INN-Spanish]
  • Acepromazine
  • Acepromazinum
  • Acepromazinum [INN-Latin]
  • Acetopromazine
  • Acetylpromazine
  • Anergan
  • Atsetozin
  • AY-57,062
  • Azepromazine
  • EC 200-496-0
  • EINECS 200-496-0
  • Notensil
  • Plegicil
  • Plivafen
  • Promazine, acetyl-
  • SV-1522
  • UNII-54EJ303F0R
  • Vetranquil
  • WY-1172

Systematic Names

  • Acepromazine
  • Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)- (9CI)
  • Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl methyl

Registry Numbers

CAS Registry Number

  • 61-00-7

FDA UNII

  • 54EJ303F0R

Related Registry Number

  • 3598-37-6 (maleate)

System Generated Number

  • 0000061007

Structure Descriptors

InChI

1S/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3

InChIKey

NOSIYYJFMPDDSA-UHFFFAOYSA-N

Smiles

CC(=O)c1ccc2c(c1)N(c3ccccc3S2)CCCN(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 350mg/kg (350mg/kg)   Revista Medico-Chirurgicala. Medical-Surgical Journal. Vol. 81, Pg. 105, 1977.
mouse LD50 intravenous 59mg/kg (59mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 1, 1958.
mouse LD50 subcutaneous 130mg/kg (130mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 53, 1957.
mouse LDLo oral 200mg/kg (200mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 53, 1957.
rat LD50 intraperitoneal 140mg/kg (140mg/kg)   Farmakologiya i Toksikologiya Vol. 24, Pg. 136, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 4.240 (none)   EST
Atmospheric OH Rate Constant 2.19E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.