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Substance Name: Methoxamine hydrochloride [USP:JAN]
RN: 61-16-5
UNII: 8MB4MJ9R7L
InChIKey: YGRFXPCHZBRUKP-WJRQTEJMSA-N

Note

  • An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.

Molecular Formula

  • C11-H17-N-O3.Cl-H

Molecular Weight

  • 247.7202
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Methoxamine hydrochloride
  • Methoxamine hydrochloride [USP:JAN]

Synonyms

  • (+-)-alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • 1-(2,5-Dimethoxyphenyl)-2-aminopropanol
  • 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol hydrochloride
  • alpha-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol hydrochloride
  • alpha-(alpha-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
  • Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
  • beta-(2,5-Dimethoxyphenyl)-beta-hydroxyisopropylamine hydrochloride
  • beta-Hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylamine hydrochloride
  • DL-2-Amino-1-(2,5-dimethoxyphenyl)propanol hydrochloride
  • EINECS 200-499-7
  • HSDB 3362
  • Idasal
  • Methoxamine HCl
  • Methoxamine hydrochloride
  • Methoxamini hydrochloridum
  • Pressomin hydrochloride
  • UNII-8MB4MJ9R7L
  • Vasoxine
  • Vasoxyl
  • Vasoxyl hydrochloride
  • Vasylox hydrochloride

Systematic Names

  • Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
  • Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
  • Methoxamine hydrochloride

Registry Numbers

CAS Registry Number

  • 61-16-5

FDA UNII

  • 8MB4MJ9R7L

Related Registry Number

  • 390-28-3 (Parent)

System Generated Number

  • 0000061165

Molecular Formulas

Molecular Formula

  • C11-H17-N-O3.Cl-H

Molecular Formula Fragments

  • C11-H17-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H/t7-,11-;/m0./s1

InChIKey

YGRFXPCHZBRUKP-WJRQTEJMSA-N

Smiles

Cl.COc1ccc(OC)c(c1)[C@@H](O)[C@H](C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 92mg/kg (92mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 283, 1948.
mouse LD50 intravenous 5030ug/kg (5.03mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse LDLo oral 135mg/kg (135mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 160, 1973.