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Substance Name: Papaverine hydrochloride [USP:JAN]
RN: 61-25-6
UNII: 23473EC6BQ
InChIKey: UOTMYNBWXDUBNX-UHFFFAOYSA-N
Note
- An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Molecular Formula
- C20-H21-N-O4.Cl-H
Molecular Weight
- 375.8498
- All
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Relaxant (Smooth Muscle)
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Papaverine hydrochloride
- Papaverine hydrochloride [USP:JAN]
Synonyms
- 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
- 6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride
- 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
- Alapav
- Artegodan
- Cardiospan
- Cardoverina
- CCRIS 3804
- Cepaverin
- Cerebid
- Cerespan
- Chlorhydrate de papaverine
- Chlorhydrate de papaverine [French]
- Delapav
- Dilaves
- Dipav
- Dispamil
- Drapavel
- Durapav
- Dynovas
- EINECS 200-502-1
- Forpavin
- Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride
- Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride
- Lapav
- Myobid
- NCI-C56359
- NSC 35443
- Optenyl
- Pameion
- PAP H
- Pap-Kaps-150
- Papacon
- Papalease
- Papanerin-HCl
- Papanerin-HCl [German]
- Papavarine chlorhydrate
- Papaverine chlorohydrate
- Papaverine HCl
- Papaverine hydrochloride
- Papaverine monohydrochloride
- Papaverinium chloride
- Papaversan
- Pavabid
- Pavacap
- Pavacen
- Pavagrant
- Pavakey
- Pavased
- Pavatest
- Paverolan
- Paveron
- Pavnell
- Ro-Papav
- Spasmo-nit
- Therapav
- UNII-23473EC6BQ
- Vasal
- Vaso-Pav
- Vasospan
Systematic Names
- Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride
- Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride (1:1)
- Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride (8CI)
- Papaverine hydrochloride
Mixture Name
- Copavin
Registry Numbers
CAS Registry Number
- 61-25-6
FDA UNII
- 23473EC6BQ
Related Registry Number
- 58-74-2 (Parent)
System Generated Number
- 0000061256
Molecular Formulas
Molecular Formula
- C20-H21-N-O4.Cl-H
Molecular Formula Fragments
- C20-H21-N-O4
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1HInChIKey
UOTMYNBWXDUBNX-UHFFFAOYSA-NSmiles
Cl.COc1ccc(Cc2nccc3cc(OC)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | 134mg/kg (134mg/kg) | Journal de Pharmacologie. Vol. 3, Pg. 47, 1972. | |
mouse | LD50 | intraperitoneal | 66mg/kg (66mg/kg) | United States Patent Document. Vol. #4405627, | |
mouse | LD50 | intravenous | 14400ug/kg (14.4mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 1109, 1989. | |
mouse | LD50 | oral | 130mg/kg (130mg/kg) | Journal of Ethnopharmacology. Vol. 6, Pg. 127, 1982. | |
mouse | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 264, 1960. | |
rabbit | LD50 | intravenous | 25mg/kg (25mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 73, 1946. | |
rat | LD50 | intraduodenal | 71mg/kg (71mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | intraperitoneal | 64mg/kg (64mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 454, 1956. | |
rat | LD50 | intravenous | 20mg/kg (20mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 264, 1960. | |
rat | LD50 | oral | 68800ug/kg (68.8mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 1109, 1989. | |
rat | LD50 | subcutaneous | 368mg/kg (368mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 454, 1956. | |
women | TDLo | oral | 300mg/kg (300mg/kg) | Clinical Toxicology. Vol. 18, Pg. 417, 1981. | |
women | TDLo | oral | 300mg/kg (300mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Clinical Toxicology. Vol. 18, Pg. 417, 1981. |