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Substance Name: Sulthiame [USAN]
RN: 61-56-3
UNII: I00Q766CZ2
InChIKey: HMHVCUVYZFYAJI-UHFFFAOYSA-N

Classification Codes

  • Anticonvulsant
  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C10-H14-N2-O4-S2

Molecular Weight

  • 290.363
 
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Names and Synonyms

Name of Substance

  • Sulthiame
  • Sulthiame [USAN]
  • Sultiame [INN]

Synonyms

  • 2-(4-Sulfamoylphenyl)-1,2-thiazixan 1,1-dioxid
  • 2-(p-Sulfamoylphenyl)-tetrahydro-2H-1,2-thiazine 1,1-dioxide
  • 2H-1,2-Thiazine, tetrahydro-2-(p-sulfamoylphenyl)-, 1,1-dioxide
  • Bayer A-168
  • BRN 1222219
  • Conadil
  • Contravul
  • EINECS 200-511-0
  • Elisal
  • Ospolot
  • p-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide, S,S-dioxide
  • R-594
  • Riker 594
  • RP 10284
  • RP-10284
  • Sulphenyltame
  • Sulthiame
  • Sulthiamine
  • Sultiame
  • Sultiamo
  • Sultiamo [INN-Spanish]
  • Sultiamum
  • Sultiamum [INN-Latin]
  • Trolone
  • UNII-I00Q766CZ2

Systematic Names

  • Benzenesulfonamide, 4-(tetrahydro-2H-1,2-thiazin-2-yl)-, S,S-dioxide
  • Benzenesulfonamide, p-(tetrahydro-2H-1,2-thiazin-2-yl)-, dioxide
  • Sultiame

Registry Numbers

CAS Registry Number

  • 61-56-3

FDA UNII

  • I00Q766CZ2

System Generated Number

  • 0000061563

Structure Descriptors

InChI

1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)

InChIKey

HMHVCUVYZFYAJI-UHFFFAOYSA-N

Smiles

c1(N2S(CCCC2)(=O)=O)ccc(S(N)(=O)=O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1668mg/kg (1668mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 306, 1972.
mouse LD50 oral 4852mg/kg (4852mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 306, 1972.
rabbit LD50 oral 1gm/kg (1000mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 306, 1972.
rat LD50 intraperitoneal 1650mg/kg (1650mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 306, 1972.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 383, 1982.
women LDLo oral 400mg/kg (400mg/kg)   Archiv fuer Toxikologie. Vol. 25, Pg. 229, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 181 deg C   EXP
log P (octanol-water) 0.980 (none)   EST
Atmospheric OH Rate Constant 2.51E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.