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Substance Name: Niridazole [USAN:INN:BAN]
RN: 61-57-4
UNII: N116U8Y5QQ
InChIKey: RDXLYGJSWZYTFJ-UHFFFAOYSA-N

Note

  • An antischistosomal agent that has become obsolete.

Molecular Formula

  • C6-H6-N4-O3-S

Molecular Weight

  • 214.2044
 

Classification Codes

Classification Codes

  • Amebicides
  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Antiprotozoal Agents
  • Antischistosomal
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Schistosomicides
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • Niridazole
  • Niridazole [USAN:INN:BAN]

MeSH Heading

  • Niridazole

Synonyms

  • 1-(5-Nitro-2-thiazolyl)-2-imidazolidinone
  • 1-(5-Nitro-2-thiazolyl)-2-imidazolinone
  • 1-(5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazole
  • AI3-51833
  • Ambilhar
  • BA 32644
  • BA 32644 Ciba
  • BRN 0665338
  • CCRIS 434
  • Ciba 32644
  • Ciba 32644-Ba
  • EINECS 200-512-6
  • HSDB 7480
  • Niridazol
  • Niridazol [INN-Spanish]
  • Niridazole
  • Niridazolum
  • Niridazolum [INN-Latin]
  • Nitrothiamidazol
  • Nitrothiamidazole
  • Nitrothiazol
  • Nitrothiazole
  • NSC 136947
  • UNII-N116U8Y5QQ

Systematic Names

  • 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-
  • Niridazole

Superlist Name

  • Niridazole

Registry Numbers

CAS Registry Number

  • 61-57-4

FDA UNII

  • N116U8Y5QQ

System Generated Number

  • 0000061574

Structure Descriptors

InChI

1S/C6H6N4O3S/c11-5-7-1-2-9(5)6-8-3-4(14-6)10(12)13/h3H,1-2H2,(H,7,11)

InChIKey

RDXLYGJSWZYTFJ-UHFFFAOYSA-N

Smiles

c1c(sc(n1)N2CCNC2=O)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 220mg/kg (220mg/kg) BEHAVIORAL: ATAXIA

KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 228, Pg. 662, 1984.
mouse LD50 oral 2500mg/kg (2500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 15, Pg. 456, 1980.
rat LD50 oral 900mg/kg (900mg/kg)   Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 17, Pg. 108, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 260-262 deg C   EXP
log P (octanol-water) 0.95 (none)   EXP
Water Solubility 130 mg/L 25 EXP
Vapor Pressure 3.45E-07 mm Hg 25 EST
Henry's Law Constant 1.12E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.09E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.