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Substance Name: Leucine [USAN:INN]
RN: 61-90-5
UNII: GMW67QNF9C
InChIKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Note

  • An essential branched-chain amino acid important for hemoglobin formation.

Molecular Formula

  • C6-H13-N-O2

Molecular Weight

  • 131.174
 

Classification Codes

  • Amino Acid
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • 2-Amino-4-methylpentanoic acid (L)
  • 2-Amino-4-methylvaleric acid (L)
  • L-Leucine
  • Leucine
  • Leucine [USAN:INN]

MeSH Heading

  • Leucine

Synonyms

  • (S)-2-Amino-4-methylpentanoic acid
  • (S)-2-Amino-4-methylvaleric acid
  • (S)-Leucine
  • 2-Amino-4-methylpentanoic acid, (S)-
  • AI3-08899
  • EC 200-522-0
  • EINECS 200-522-0
  • FEMA No. 3297
  • HSDB 7799
  • L-(-)-2-Amino-4-methylpentanoic acid
  • L-alpha-Aminoisocaproic acid
  • L-Leucine
  • L-Norvaline, 4-methyl-
  • Leu
  • Leucin
  • Leucin [German]
  • Leucina
  • Leucina [INN-Spanish]
  • Leucina [Latin,Spanish]
  • Leucine
  • Leucine (VAN)
  • Leucinum
  • Leucinum [INN-Latin]
  • NSC 46709
  • Pentanoic acid, 2-amino-4-methyl-, (S)-
  • UNII-GMW67QNF9C
  • Valeric acid, 2-amino-4-methyl-, (S)-

Systematic Names

  • L-Leucine
  • Leucine
  • Leucine (VAN)

Superlist Name

  • Leucine, L-

Registry Numbers

CAS Registry Number

  • 61-90-5

FDA UNII

  • GMW67QNF9C

Other Registry Number

  • 7005-03-0

System Generated Number

  • 0000061905

Structure Descriptors

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChIKey

ROHFNLRQFUQHCH-YFKPBYRVSA-N

Smiles

C([C@@H](C(O)=O)N)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LDLo subcutaneous 2620mg/kg (2620mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 40, Pg. 313, 1898.
rat LD50 intraperitoneal 5379mg/kg (5379mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 293 deg C   EXP
pKa Dissociation Constant 2.348 (none) 13 EXP
log P (octanol-water) -1.52E+00 (none)   EXP
Water Solubility 2.15E+04 mg/L 25 EXP
Vapor Pressure 1.34E-08 mm Hg 25 EST
Henry's Law Constant 3.49E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.23E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.