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Substance Name: Bromhexine hydrochloride [USAN:JAN]
RN: 611-75-6
UNII: YC2ZOM3Z8V
InChIKey: UCDKONUHZNTQPY-UHFFFAOYSA-N

Note

  • A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)

Molecular Formula

  • C14-H20-Br2-N2.Cl-H

Molecular Weight

  • 412.5949
 

Classification Codes

  • Drug / Therapeutic Agent
  • Expectorant
  • Mucolytic
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Names and Synonyms

Name of Substance

  • Bromhexine hydrochloride [USAN:JAN]

Synonyms

  • 2-Amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride
  • 3,5-Dibromo-N(sup alpha)-cyclohexyl-N(sup alpha)-methyltoluene-alpha,2-diamine monohydrochloride
  • Auxit
  • Benzylamine, 2-amino-N-cyclohexyl-3,5-dibromo-N-methyl-, hydrochloride
  • Bisolvon
  • Bromessina
  • Bromessina [Italian]
  • Bromhexine chloride
  • Bromhexine HCl
  • Bromhexine hydrochloride
  • Bromihexine hydrochloride
  • Bromohexine monohydrochloride
  • Broncokin
  • EINECS 210-280-8
  • Lisomucin
  • N-(2-Amino-3,5-dibromobenzyl)-N-methyl-cyclohexylammonium chloride
  • N-Cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium chloride
  • NA 274
  • UNII-YC2ZOM3Z8V
  • Viscolyt

Systematic Names

  • Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride
  • Bromhexine hydrochloride
  • Toluene-alpha,2-diamine, 3,5-dibromo-N(sup alpha)-cyclohexyl-N-(sup alpha)-methyl-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 611-75-6

FDA UNII

  • YC2ZOM3Z8V

Related Registry Number

  • 3572-43-8 (Parent)

System Generated Number

  • 0000611756

Molecular Formulas

Molecular Formula

  • C14-H20-Br2-N2.Cl-H

Molecular Formula Fragments

  • C14-H20-Br2-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

InChIKey

UCDKONUHZNTQPY-UHFFFAOYSA-N

Smiles

c1(c(c(cc(c1)Br)Br)N)CN(C1CCCCC1)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2210mg/kg (2210mg/kg)   Gendai no Rinsho. Vol. 3, Pg. 259, 1969.
mouse LD50 intravenous 44mg/kg (44mg/kg)   Gendai no Rinsho. Vol. 3, Pg. 259, 1969.
mouse LD50 oral 3gm/kg (3000mg/kg)   Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 109, Pg. 385, 1970.
mouse LD50 subcutaneous > 14gm/kg (14000mg/kg)   Drugs in Japan Vol. 6, Pg. 737, 1982.
rabbit LD50 oral 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 284, 1966.
rat LD50 intraperitoneal 1680mg/kg (1680mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.
rat LD50 oral 6gm/kg (6000mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.
rat LD50 subcutaneous > 14gm/kg (14000mg/kg)   Yakkyoku. Pharmacy. Vol. 35(1), Pg. -, 1984.