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Substance Name: Clavulanate potassium [USAN:USP:JAN]
RN: 61177-45-5
UNII: Q42OMW3AT8
InChIKey: ABVRVIZBZKUTMK-JSYANWSFSA-M

Classification Codes

  • Antibacterial
  • Inhibitor (beta-Lactamase)
  • Reproductive Effect

Molecular Formulas

  • C8-H8-K-N-O5
  • C8-H8-N-O5.K
  • C8-H9-N-O5.K

Molecular Weight

  • 237.2512
 
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Names and Synonyms

Name of Substance

  • Clavulanate potassium [USAN:USP:JAN]

Synonyms

  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2alpha,3Z,5alpha))-
  • Amonate
  • BRL 14151K
  • Clavulanate potassium
  • Clavulansaeure kaliumsalz
  • EINECS 262-640-9
  • Potassium (Z)-(2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylate
  • Potassium clavulanate
  • UNII-Q42OMW3AT8

Systematic Names

  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2alpha,3Z,5alpha))-
  • Potassium (2R-(2alpha,3Z,5alpha))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylate

Mixture Names

  • Augmentin
  • Timentin

Registry Numbers

CAS Registry Number

  • 61177-45-5

FDA UNII

  • Q42OMW3AT8

Related Registry Number

  • 58001-44-8 (Parent)

System Generated Number

  • 0061177455

Molecular Formulas

Molecular Formulas

  • C8-H8-K-N-O5
  • C8-H8-N-O5.K
  • C8-H9-N-O5.K

Molecular Formula Fragments

  • C8-H8-N-O5
  • C8-H9-N-O5
  • COMPONENT
  • K

Structure Descriptors

InChI

InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1

InChIKey

ABVRVIZBZKUTMK-JSYANWSFSA-M

Smiles

[K+].OC\C=C\1/O[C@@H]2CC(=O)N2[C@H]1C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 34(Suppl,
mouse LD50 intraperitoneal 1531mg/kg (1531mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 31(Suppl,
mouse LD50 intravenous 348mg/kg (348mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 34(Suppl,
mouse LD50 oral 4526mg/kg (4526mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
mouse LD50 subcutaneous 2185mg/kg (2185mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 31(Suppl,
rat LD50 intramuscular 1680mg/kg (1680mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Chemotherapy Vol. 34(Suppl,
rat LD50 intraperitoneal 1399mg/kg (1399mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 31(Suppl,
rat LD50 intravenous 326mg/kg (326mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 34(Suppl,
rat LD50 oral 7936mg/kg (7936mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 subcutaneous 1398mg/kg (1398mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 31(Suppl,