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Substance Name: Rifapentine [USAN:INN:BAN]
RN: 61379-65-5
UNII: XJM390A33U
InChIKey: WDZCUPBHRAEYDL-GZAUEHORSA-N
Note
- Cyclopentyl derivative of rifampicin.
Molecular Formula
- C47-H64-N4-O12
Molecular Weight
- 877.0386
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Antibiotics, Antitubercular
- Antitubercular Agents
- Drug / Therapeutic Agent
- Leprostatic Agents
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Names and Synonyms
Name of Substance
- Rifapentine
- Rifapentine [USAN:INN:BAN]
Synonyms
- 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
- 3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
- 3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
- Antibiotic DL 473IT
- Cyclopentylrifampicin
- DL 473
- DRG-0283
- EINECS 262-743-9
- KTC 1
- MDL 473
- Priftin
- R 77-3
- R-773
- Rifamycin AF/ACPP
- Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-
- Rifapentina
- Rifapentina [Spanish]
- Rifapentine
- Rifapentinum
- Rifapentinum [Latin]
- UNII-XJM390A33U
Systematic Names
- Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-
- Rifapentine
Registry Numbers
CAS Registry Number
- 61379-65-5
FDA UNII
- XJM390A33U
Other Registry Numbers
- 71950-35-1
- 773848-08-1
System Generated Number
- 0061379655
Structure Descriptors
InChI
InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1InChIKey
WDZCUPBHRAEYDL-GZAUEHORSA-NSmiles
CO[C@H]1\C=C\O[C@@]2(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 710mg/kg (710mg/kg) | Journal of Antibiotics. Vol. 34, Pg. 1026, 1981. | |
mouse | LD50 | oral | 3300mg/kg (3300mg/kg) | Journal of Antibiotics. Vol. 34, Pg. 1026, 1981. | |
rat | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 242, 1992. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 242, 1992. |