Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Triprolidine hydrochloride [USP:JAN]
RN: 6138-79-0
UNII: YAN7R5L890
InChIKey: CUZMOIXUFHOLLN-UMVVUDSKSA-N

Note

  • Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

Molecular Formula

  • C19-H22-N2.Cl-H.H2-O

Molecular Weight

  • 332.8725
 

Classification Codes

  • Anti-Allergic Agents
  • Antihistaminic
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Triprolidine hydrochloride monohydrate
  • Triprolidine hydrochloride [USP:JAN]

Synonyms

  • (E)-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride monohydrate
  • Actidil
  • CCRIS 7215
  • Myidyl
  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, monohydrate, (E)-
  • Triprolidine HCl
  • Triprolidine hydrochloride
  • Triprolidine hydrochloride monohydrate
  • UNII-YAN7R5L890

Systematic Names

  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, monohydrate, (E)-
  • Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, monohydrate, stereoisomer
  • Triprolidine hydrochloride

Mixture Names

  • Actifed
  • Actifed Plus
  • Actifed with Codeine Cough Syrup
  • Bayer Select Night Time Cold

Registry Numbers

CAS Registry Number

  • 6138-79-0

FDA UNII

  • YAN7R5L890

Related Registry Number

  • 486-12-4 (Parent)

System Generated Number

  • 0006138790

Molecular Formulas

Molecular Formula

  • C19-H22-N2.Cl-H.H2-O

Molecular Formula Fragments

  • C19-H22-N2
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;

InChIKey

CUZMOIXUFHOLLN-UMVVUDSKSA-N

Smiles

Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3.O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 163mg/kg (163mg/kg)   National Center for Toxicology Research Technical Report. Office of Associate Director for Scientific Coordination, Jefferson, Arkansas 72079Vol. #414/415, Pg. 1991,
rat LD50 oral 840mg/kg (840mg/kg)   National Center for Toxicology Research Technical Report. Office of Associate Director for Scientific Coordination, Jefferson, Arkansas 72079Vol. #414/415, Pg. 1991,