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Substance Name: Rolipram [USAN:INN]
RN: 61413-54-5
UNII: K676NL63N7
InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N

Note

  • A phosphodiesterase 4 inhibitor with antidepressant properties.

Molecular Formula

  • C16-H21-N-O3

Molecular Weight

  • 275.3459
 

Classification Codes

  • Antidepressive Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Phosphodiesterase 4 Inhibitors
  • Phosphodiesterase Inhibitors
  • Psychotropic Drugs
  • Tranquilizer
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Names and Synonyms

Name of Substance

  • Rolipram
  • Rolipram [USAN:INN]

MeSH Heading

  • Rolipram

Synonyms

  • 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
  • 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
  • BRN 1588548
  • EINECS 262-771-1
  • NSC 760125
  • Rolipram
  • Rolipramum
  • Rolipramum [Latin]
  • UNII-K676NL63N7
  • ZK 62 711
  • ZK 62711

Systematic Names

  • 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
  • 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
  • Rolipram

Registry Numbers

CAS Registry Number

  • 61413-54-5

FDA UNII

  • K676NL63N7

System Generated Number

  • 0061413545

Structure Descriptors

InChI

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChIKey

HJORMJIFDVBMOB-UHFFFAOYSA-N

Smiles

COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 300mg/kg (300mg/kg)   Biological and Pharmaceutical Bulletin. Vol. 17, Pg. 498, 1994.