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Substance Name: N-Nitroso-N-methylurethane
RN: 615-53-2
UNII: 741GDM4803
InChIKey: CAUBWLYZCDDYEF-UHFFFAOYSA-N

Note

  • An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.

Molecular Formula

  • C4-H8-N2-O3

Molecular Weight

  • 132.118
 

Classification Codes

Classification Codes

  • Alkylating Agents
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • TSCA Flag S (Substance is Identified in a Proposed or Final SNUR (Significant New Use Rule) under TSCA)
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reportable Quantity (RQ) = 1 lb
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Names and Synonyms

Name of Substance

  • N-Nitroso-N-methylurethane
  • Nitrosomethylurethane

MeSH Heading

  • Nitrosomethylurethane

Synonyms

  • 4-04-00-03385 (Beilstein Handbook Reference)
  • AI3-19393
  • BRN 1763954
  • Carbamic acid, methylnitroso-, ethyl ester
  • Carbamic acid, N-methyl-N-nitroso-, ethyl ester
  • CCRIS 471
  • EINECS 210-432-3
  • Ethyl ester of methylnitroso-carbamic acid
  • Ethyl N-methylnitrosocarbamate
  • Ethylester kyseliny N-methyl-N-nitrosokarbaminove
  • Ethylester kyseliny N-methyl-N-nitrosokarbaminove [Czech]
  • HSDB 5113
  • Methyl-N-nitrosourethane
  • Methylnitrosourethan
  • Methylnitrosourethan [German]
  • Methylnitrosourethane
  • MNUN
  • N-Methyl-N-nitroso-urethane
  • N-Methyl-N-nitrosocarbamic acid, ethyl ester
  • N-Methyl-N-nitrosoethylcarbamate
  • N-Nitro-N-methylurethan
  • N-Nitroso-N-methylurethane
  • N-Nitrosomethylurethane
  • Nitrosomethylurethan
  • Nitrosomethylurethan [German]
  • Nitrosomethylurethane
  • NM-Urethan
  • Nm-urethane
  • NMU
  • NMUT
  • NSC 2860
  • RCRA waste number U178
  • UNII-741GDM4803

Systematic Names

  • Carbamic acid, methylnitroso-, ethyl ester
  • Carbamic acid, N-methyl-N-nitroso-, ethyl ester
  • Ethyl methylnitrosocarbamate
  • N-Nitroso-N-methylurethane

Superlist Names

  • Carbamic acid, methylnitroso-, ethyl ester
  • N-Methyl-N-nitrosourethane
  • N-Nitroso-N-methylurethane
  • Nitrosomethylurethane
  • RCRA waste no. U178

Registry Numbers

CAS Registry Number

  • 615-53-2

FDA UNII

  • 741GDM4803

System Generated Number

  • 0000615532

Structure Descriptors

InChI

1S/C4H8N2O3/c1-3-9-4(7)6(2)5-8/h3H2,1-2H3

InChIKey

CAUBWLYZCDDYEF-UHFFFAOYSA-N

Smiles

C(N(N=O)C)(OCC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LDLo subcutaneous 21mg/kg (21mg/kg)   American Journal of Pathology. Vol. 50, Pg. 639, 1967.
mammal (species unspecified) LD50 intravenous 4mg/kg (4mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mammal (species unspecified) LD50 oral 240mg/kg (240mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mouse LCLo inhalation 600mg/m3/10M (600mg/m3)   National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. MAR1942,
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   Cancer Research. Vol. 30, Pg. 11, 1970.
mouse LDLo subcutaneous 7mg/kg (7mg/kg)   British Journal of Cancer. Vol. 23, Pg. 167, 1969.
rat LD50 intravenous 4mg/kg (4mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
rat LD50 oral 180mg/kg (180mg/kg)   Naturwissenschaften. Vol. 48, Pg. 165, 1961.
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   British Journal of Cancer. Vol. 22, Pg. 316, 1968.
rat LDLo subcutaneous 125mg/kg (125mg/kg)   British Journal of Cancer. Vol. 16, Pg. 92, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.220 (none)   EST
Water Solubility 3.70E+04 mg/L 25 EXP
Henry's Law Constant 5.54E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.92E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.