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Substance Name: Oxytetracycline, disodium salt, dihydrate
RN: 6153-65-7
InChIKey: JASPHSIQIMDZNL-ODQZHCRPSA-L

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H24-N2-O9.2Na.2H2-O

Molecular Weight

  • 540.4304
 
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Names and Synonyms

Name of Substance

  • Oxytetracycline, disodium salt, dihydrate

Synonyms

  • Oxytetracycline, disodium salt, dihydrate
  • Sodium terramycin

Systematic Name

  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, disodium deriv., dihydrate

Registry Numbers

CAS Registry Number

  • 6153-65-7

Related Registry Number

  • 79-57-2 (Parent)

System Generated Number

  • 0006153657

Molecular Formulas

Molecular Formula

  • C22-H24-N2-O9.2Na.2H2-O

Molecular Formula Fragments

  • C22-H24-N2-O9
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/C22H24N2O9.2Na.2H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;;;;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);;;2*1H2/q;2*+1;;/p-2/t12-,13-,14+,17+,21-,22+;;;;/m1..../s1

InChIKey

JASPHSIQIMDZNL-ODQZHCRPSA-L

Smiles

C[C@]1(c2cccc(c2C(=O)C3=C([C@]4([C@@H]([C@H]([C@@H]31)O)[C@@H](C(=C(C4=O)C(=O)N)O)N(C)C)O)[O-])[O-])O.O.O.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 60mg/kg (60mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
mouse LD50 intravenous 205mg/kg (205mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
mouse LD50 subcutaneous 316mg/kg (316mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.
rabbit LDLo intravenous 120mg/kg (120mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 234, 1950.