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Substance Name: Acetylcysteine [USAN:USP:INN:BAN:JAN]
RN: 616-91-1
UNII: WYQ7N0BPYC
InChIKey: PWKSKIMOESPYIA-BYPYZUCNSA-N

Note

  • The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.

Molecular Formula

  • C5-H9-N-O3-S

Molecular Weight

  • 163.1961
 

Classification Codes

  • Anti-Infective Agents
  • Antioxidants
  • Antiretroviral
  • Antiviral Agents
  • Expectorants
  • Free Radical Scavengers
  • Human Data
  • Mucolytic
  • Respiratory System Agents

Names and Synonyms

Name of Substance

  • Acetylcysteine
  • Acetylcysteine [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Acetylcysteine

Synonyms

  • 5052
  • Acetadote
  • Acetein
  • Acetilcisteina
  • Acetilcisteina [INN-Spanish]
  • Acetylcysteine
  • Acetylcysteinum
  • Acetylcysteinum [INN-Latin]
  • Airbron
  • Broncholysin
  • Brunac
  • CCRIS 3764
  • Cetylev
  • component of Naxid
  • Cysteine, N-acetyl-, L-
  • EINECS 210-498-3
  • Exomuc
  • Fabrol
  • Fluimicil Infantil
  • Fluimucetin
  • Fluimucil
  • Flumil
  • Flumucetin
  • Fluprowit
  • HSDB 3003
  • Inspir
  • L-Acetylcysteine
  • L-alpha-Acetamido-beta-mercaptopropionic acid
  • L-Cysteine, N-acetyl-
  • Lysomucil
  • Mercapturic acid
  • Mercapturic acid, (R)-
  • Mucofilin
  • Mucolyticum Lappe
  • Mucolyticum-Lappe
  • Mucolytikum Lappe
  • Mucomyst
  • Mucosil
  • Mucosil-10
  • Mucosil-20
  • Mucosolvin
  • N-Acetyl cysteine
  • N-Acetyl-3-mercaptoalanine
  • N-Acetyl-L-cysteine
  • N-Acetylcysteine
  • NAC
  • NAC-TB
  • Neo-Fluimucil
  • NSC 111180
  • Parvolex
  • Respaire
  • Syntemucol
  • UNII-WYQ7N0BPYC

Systematic Names

  • Acetylcysteine
  • Cysteine, N-acetyl-, L-
  • L-Cysteine, N-acetyl-
  • N-Acetyl-L-cysteine

Mixture Name

  • Naxid

Registry Numbers

CAS Registry Number

  • 616-91-1

FDA UNII

  • WYQ7N0BPYC

Other Registry Numbers

  • 1261105-20-7
  • 7696-05-1

Related Registry Numbers

  • 18829-79-3 (hydrochloride)
  • 19542-74-6 (mono-hydrochloride salt)
  • 63664-54-0 (hydrochloride salt)

System Generated Number

  • 0000616911

Structure Descriptors

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChIKey

PWKSKIMOESPYIA-BYPYZUCNSA-N

Smiles

[C@@H](NC(=O)C)(C(=O)O)CS

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo multiple routes 8480mg/kg/3D- (8480mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Pediatrics. Vol. 79, Pg. 281, 1987.
dog LD50 intraperitoneal 700mg/kg (700mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
dog LD50 intravenous 700mg/kg (700mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
dog LD50 oral > 1gm/kg (1000mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 intravenous 3800mg/kg (3800mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Medicinal Chemistry. Vol. 10, Pg. 1172, 1967.
mouse LD50 oral 4400mg/kg (4400mg/kg)   European Patent Application. Vol. #0192191,
rat LD50 intravenous 1140mg/kg (1140mg/kg) GASTROINTESTINAL: OTHER CHANGES European Journal of Respiratory Diseases. Vol. 61(Suppl,
rat LD50 oral 5050mg/kg (5050mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 109.5 deg C   EXP
log P (octanol-water) -0.660 (none)   EST
Atmospheric OH Rate Constant 5.49E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.