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Substance Name: Cefotiam [INN:BAN]
RN: 61622-34-2
UNII: 91W6Z2N718
InChIKey: QYQDKDWGWDOFFU-IUODEOHRSA-N

Note

  • One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

Molecular Formula

  • C18-H23-N9-O4-S3

Molecular Weight

  • 525.6367
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Cefotiam
  • Cefotiam [INN:BAN]

MeSH Heading

  • Cefotiam

Synonyms

  • Cefotiam
  • Cefotiamum
  • Cefotiamum [INN-Latin]
  • CGP 14221E
  • CTM
  • UNII-91W6Z2N718

Systematic Name

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-trans)-

Registry Numbers

CAS Registry Number

  • 61622-34-2

FDA UNII

  • 91W6Z2N718

Other Registry Numbers

  • 67356-92-7
  • 70896-40-1

System Generated Number

  • 0061622342

Structure Descriptors

InChI

1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1

InChIKey

QYQDKDWGWDOFFU-IUODEOHRSA-N

Smiles

CN(C)CCn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4csc(N)n4)C3=O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 3840mg/kg (3840mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 296, 1982.
mouse LD50 subcutaneous 7800mg/kg (7800mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 296, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.400 (none)   EST
Atmospheric OH Rate Constant 2.09E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.