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Substance Name: Fluvoxamine maleate [USAN:USP]
RN: 61718-82-9
UNII: 5LGN83G74V
InChIKey: LFMYNZPAVPMEGP-PIDGMYBPSA-N

Note

  • A selective serotonin reuptake inhibitor. It is effective in the treatment of depression, obsessive-compulsive disorders, anxiety, panic disorders, and alcohol amnestic disorders.

Molecular Formula

  • C15-H21-F3-N2-O2.C4-H4-O4

Molecular Weight

  • 434.4085
 

Classification Codes

  • Antiobsessional Agent
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Fluvoxamine maleate [USAN:USP]

Synonyms

  • 5-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime, maleate (1:1)
  • 5-Methoxy-4'-trifluoromethylvalerophenone (E)-O-2-aminoethyloxime monomaleate
  • DU23000
  • Fevarin
  • Fluvoxamine maleate
  • Luvox
  • Luvox CR
  • SME 3110
  • UNII-5LGN83G74V

Systematic Name

  • 1-Pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, O-(2-aminoethyl)oxime, (E)-, (Z)-2-butenedioate (1:1)

Registry Numbers

CAS Registry Number

  • 61718-82-9

FDA UNII

  • 5LGN83G74V

Related Registry Number

  • 54739-18-3 (Parent)

System Generated Number

  • 0061718829

Molecular Formulas

Molecular Formula

  • C15-H21-F3-N2-O2.C4-H4-O4

Molecular Formula Fragments

  • C15-H21-F3-N2-O2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-

InChIKey

LFMYNZPAVPMEGP-PIDGMYBPSA-N

Smiles

COCCCC\C(=N/OCCN)\c1ccc(cc1)C(F)(F)F.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 464mg/kg (464mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 395, 2000.
human TDLo oral 64286ug/kg (64.286mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: WAKEFULNESS
Journal of International Medical Research. Vol. 21, Pg. 197, 1993.
man TDLo oral 175mg/kg/13W- (175mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 38, Pg. 942, 1999.
mouse LD50 oral 1100mg/kg (1100mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of International Medical Research. Vol. 21, Pg. 197, 1993.
rat LDLo oral 1500mg/kg (1500mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4149, 1994.
rat LDLo oral 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4149, 1994.
women TDLo oral 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
Medical Toxicology. Vol. 1, Pg. 411, 1986.