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Substance Name: Oxaliplatin [USAN:USP:INN:BAN]
RN: 61825-94-3
UNII: 04ZR38536J
InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L

Note

  • An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

Molecular Formula

  • C8-H14-N2-O4-Pt

Molecular Weight

  • 397.2886
 

Classification Codes

  • Antineoplastic
  • Antineoplastic (DNA Adduct Alkylating Agent)
  • Antineoplastic Agents
  • Antineoplatic (DNA Adduct Alkylating Agent)
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Oxaliplatin
  • Oxaliplatin [USAN:USP:INN:BAN]

MeSH Heading

  • Oxaliplatin

Synonyms

  • (SP-4-2-(1R-trans))-(1,2-Cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum
  • 1-OHP
  • CCRIS 9143
  • cis-((1R,2R)-1,2-Cyclohexanediamine-N,N')(oxalato(2-)-O,O')platinum
  • Dacplat
  • Eloxatin
  • Elplat
  • JM-83
  • l-OHP
  • Lipoxal
  • NSC 266046
  • Oxalato(1R,2R-cyclohexanediammine)platinum(II)
  • Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
  • Oxalato(trans-1-1,2-cyclohexanediamine)platinum(II)
  • Oxalatoplatin
  • Oxalatoplatinum
  • Oxaliplatin
  • Oxaliplatino
  • Oxaliplatino [Spanish]
  • Oxaliplatinum
  • Oxaliplatinum [Latin]
  • Oxalitin
  • Oxaloplatine
  • Oxaloplatine [French]
  • Oxaloplatino
  • Oxaloplatino [Spanish]
  • RP 54780
  • RP-54780
  • SR 96669
  • SR-96669
  • trans-l-Diaminocyclohexane oxalatoplatinum
  • UNII-04ZR38536J

Systematic Names

  • Platinum, ((1R,2R)-1,2-cyclohexanediamine-kappaN,kappaN')(ethanedioato(2-)-kappaO1,kappaO2)-, (SP-4-2)-
  • Platinum, (1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')-, (SP-4-2-(1R-trans))-

Registry Numbers

CAS Registry Number

  • 61825-94-3

FDA UNII

  • 04ZR38536J

Related Registry Number

  • 63121-00-6 (SP-4-2 (trans))

System Generated Number

  • 0061825943

Structure Descriptors

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChIKey

ZROHGHOFXNOHSO-BNTLRKBRSA-L

Smiles

O=C1C(=O)[O-][Pt+2]2([NH2][C@@H]3CCCC[C@H]3[NH2]2)[O-]1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 19800ug/kg (19.8mg/kg)   Drugs of the Future. Vol. 14, Pg. 529, 1989.
rat LD50 intraperitoneal 14300ug/kg (14.3mg/kg)   Drugs of the Future. Vol. 14, Pg. 529, 1989.