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Substance Name: Oxaliplatin [USAN:USP:INN:BAN]
RN: 61825-94-3
UNII: 04ZR38536J
InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L

Classification Codes

  • Antineoplastic
  • Antineoplastic (DNA Adduct Alkylating Agent)
  • Antineoplastic Agents
  • Antineoplatic (DNA Adduct Alkylating Agent)
  • Drug / Therapeutic Agent

Molecular Formula

  • C8-H14-N2-O4-Pt

Molecular Weight

  • 397.2886
 

Names and Synonyms

Name of Substance

  • Oxaliplatin
  • Oxaliplatin [USAN:USP:INN:BAN]

Synonyms

  • (SP-4-2-(1R-trans))-(1,2-Cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum
  • 1-OHP
  • CCRIS 9143
  • cis-((1R,2R)-1,2-Cyclohexanediamine-N,N')(oxalato(2-)-O,O')platinum
  • Dacplat
  • Eloxatin
  • Elplat
  • JM-83
  • l-OHP
  • Lipoxal
  • NSC 266046
  • Oxalato(1R,2R-cyclohexanediammine)platinum(II)
  • Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
  • Oxalato(trans-1-1,2-cyclohexanediamine)platinum(II)
  • Oxalatoplatin
  • Oxalatoplatinum
  • Oxaliplatin
  • Oxaliplatino
  • Oxaliplatino [Spanish]
  • Oxaliplatinum
  • Oxaliplatinum [Latin]
  • Oxalitin
  • Oxaloplatine
  • Oxaloplatine [French]
  • Oxaloplatino
  • Oxaloplatino [Spanish]
  • RP 54780
  • RP-54780
  • SR 96669
  • SR-96669
  • trans-l-Diaminocyclohexane oxalatoplatinum
  • UNII-04ZR38536J

Systematic Names

  • Platinum, ((1R,2R)-1,2-cyclohexanediamine-kappaN,kappaN')(ethanedioato(2-)-kappaO1,kappaO2)-, (SP-4-2)-
  • Platinum, (1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')-, (SP-4-2-(1R-trans))-

Registry Numbers

CAS Registry Number

  • 61825-94-3

FDA UNII

  • 04ZR38536J

Related Registry Number

  • 63121-00-6 (SP-4-2 (trans))

System Generated Number

  • 0061825943

Structure Descriptors

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChIKey

ZROHGHOFXNOHSO-BNTLRKBRSA-L

Smiles

O=C1C(=O)[O-][Pt+2]2([NH2][C@@H]3CCCC[C@H]3[NH2]2)[O-]1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 19800ug/kg (19.8mg/kg)   Drugs of the Future. Vol. 14, Pg. 529, 1989.
rat LD50 intraperitoneal 14300ug/kg (14.3mg/kg)   Drugs of the Future. Vol. 14, Pg. 529, 1989.