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Substance Name: Paroxetine [USAN:INN:BAN]
RN: 61869-08-7
UNII: 41VRH5220H
InChIKey: AHOUBRCZNHFOSL-YOEHRIQHSA-N
Note
- A serotonin uptake inhibitor that is effective in the treatment of depression.
Molecular Formula
- C19-H20-F-N-O3
Molecular Weight
- 329.369
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antidepressant
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Human Data
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Reproductive Effect
- Serotonin Agents
- Serotonin Uptake Inhibitors
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Links to Resources
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Names and Synonyms
Name of Substance
- Paroxetine
- Paroxetine [USAN:INN:BAN]
MeSH Heading
- Paroxetine
Synonyms
- (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
- (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-methylenedioxy)phenoxy)methyl)piperidine
- BRL 29060
- Casbol
- FG 7051
- Frosinor
- HSDB 7175
- Motivan
- Oxetine
- Paroxetina
- Paroxetina [INN-Spanish]
- Paroxetine
- Paroxetinum
- Paroxetinum [INN-Latin]
- Paxetil
- Paxil
- Paxil CR
- PaxPar
- Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S,4R)-
- Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-
- UNII-41VRH5220H
Systematic Names
- Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S,4R)-
- Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-
Registry Numbers
CAS Registry Number
- 61869-08-7
FDA UNII
- 41VRH5220H
Other Registry Number
- 63952-24-9
Related Registry Numbers
- 110429-35-1 (HCl hemihydrate)
- 64006-44-6 (maleate)
- 72471-80-8 (acetate)
- 78246-49-8 (hydrochloride)
System Generated Number
- 0061869087
Structure Descriptors
InChI
InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1InChIKey
AHOUBRCZNHFOSL-YOEHRIQHSA-NSmiles
Fc1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 6700ug/kg (6.7mg/kg) | BEHAVIORAL: EXCITEMENT | American Journal of Emergency Medicine. Vol. 11, Pg. 682, 1993. |
women | TDLo | oral | 400ug/kg (0.4mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS | Journal of Clinical Psychiatry. Vol. 58, Pg. 175, 1997. |
women | TDLo | oral | 400ug/kg (0.4mg/kg) | BEHAVIORAL: REGIDITY PERIPHERAL NERVE AND SENSATION: FASCICULATIONS | British Journal of Psychiatry. Vol. 169, Pg. 522, 1996. |
women | TDLo | oral | 1400ug/kg/7W- (1.4mg/kg) | American Journal of Psychiatry. Vol. 153, Pg. 134, 1996. | |
women | TDLo | oral | 2800ug/kg/7D- (2.8mg/kg) | Medical Journal of Australia. Vol. 163, Pg. 390, 1995. | |
women | TDLo | oral | 2800ug/kg/7D- (2.8mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Medical Journal of Australia. Vol. 163, Pg. 390, 1995. |
women | TDLo | oral | 4200ug/kg/3W- (4.2mg/kg) | ENDOCRINE: HYPERGLYCEMIA | Annals of Internal Medicine. Vol. 125, Pg. 782, 1996. |
women | TDLo | oral | 5600ug/kg/2W- (5.6mg/kg) | BEHAVIORAL: IRRITABILITY BEHAVIORAL: WAKEFULNESS BEHAVIORAL: TOXIC PSYCHOSIS | Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 36, Pg. 445, 1997. |
women | TDLo | oral | 8400ug/kg/21D (8.4mg/kg) | Netherlands Journal of Medicine. Vol. 51, Pg. 237, 1997. | |
women | TDLo | oral | 8400ug/kg/21D (8.4mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: COMA | Netherlands Journal of Medicine. Vol. 51, Pg. 237, 1997. |
women | TDLo | oral | 11200ug/kg/8W (11.2mg/kg) | PERIPHERAL NERVE AND SENSATION: FASCICULATIONS | Journal of Clinical Pyschopharmacology. Vol. 16, Pg. 258, 1996. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 3.950 | (none) | EST | |
Atmospheric OH Rate Constant | 1.64E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.