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Substance Name: Dopamine hydrochloride [USAN:USP:JAN]
RN: 62-31-7
UNII: 7L3E358N9L
InChIKey: CTENFNNZBMHDDG-UHFFFAOYSA-N

Note

  • One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Molecular Formula

  • C8-H11-N-O2.Cl-H

Molecular Weight

  • 189.641
 

Classification Codes

  • Adrenergic
  • Adrenergic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dopamine hydrochloride [USAN:USP:JAN]

Synonyms

  • 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
  • 3,4-Dihydroxyphenethylamine hydrochloride
  • 3-Hydroxytyramine hydrochloride
  • 4-(2-Aminoethyl)pyrocatechol hydrochloride
  • Abbodop
  • ASL 279
  • ASL-279
  • beta-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
  • Dopamine chloride
  • Dopamine HCl
  • Dopamine hydrochloride
  • Dopamine hydrochloride and dextrose 5%
  • Dopamine hydrochloride and dextrose 5% in plastic container
  • Dopamine hydrochloride in dextrose 5%
  • Dopamine hydrochloride in dextrose 5% in plastic container
  • Dopastat
  • Dynatra
  • EINECS 200-527-8
  • Intropin
  • m-Hydroxytyramine hydrochloride
  • NSC 169105
  • P 498
  • Revivan
  • UNII-7L3E358N9L

Systematic Names

  • 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
  • 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1)
  • Dopamine hydrochloride
  • Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 62-31-7

FDA UNII

  • 7L3E358N9L

Other Registry Numbers

  • 1477-71-0
  • 2002410-63-9

Related Registry Number

  • 51-61-6 (Parent)

System Generated Number

  • 0000062317

Molecular Formulas

Molecular Formula

  • C8-H11-N-O2.Cl-H

Molecular Formula Fragments

  • C8-H11-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

InChIKey

CTENFNNZBMHDDG-UHFFFAOYSA-N

Smiles

c1(cc(c(O)cc1)O)CCN.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 79mg/kg (79mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 2208, 1978.
man TDLo intravenous 1429ug/kg (1.429mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Critical Care Medicine. Vol. 9, Pg. 658, 1981.
mouse LD50 intraperitoneal 914mg/kg (914mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
mouse LD50 intravenous 156mg/kg (156mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
mouse LD50 oral 4361mg/kg (4361mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
mouse LD50 subcutaneous 1366mg/kg (1366mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
rabbit LD50 intravenous 90mg/kg (90mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
rat LD50 intraperitoneal 597mg/kg (597mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
rat LD50 intravenous 4800ug/kg (4.8mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
rat LD50 oral 2859mg/kg (2859mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.
rat LD50 subcutaneous 647mg/kg (647mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2311, 1974.