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Substance Name: Chlormerodrin [INN:BAN:NF]
RN: 62-37-3
UNII: 99T5TWO621
InChIKey: RWPUPAVPTLMBLV-UHFFFAOYSA-M

Note

  • A mercurial compound that has been used as a diuretic but is now superseded by more potent and less toxic drugs. The radiolabeled form has been used as a diagnostic and research tool.

Molecular Formula

  • C5-H11-Cl-Hg-N2-O2

Molecular Weight

  • 366.189
 

Classification Codes

  • Drug / Therapeutic Agent
  • Organometallic
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Names and Synonyms

Name of Substance

  • Chlormerodrin
  • Chlormerodrin [INN:BAN:NF]

MeSH Heading

  • Chlormerodrin

Synonyms

  • (3-((Aminocarbonyl)amino)-2-methoxypropyl)chloromercury
  • (3-(Chloromercuri)-2-methoxypropyl))urea
  • 1-(3-(Chloromercuri)-2-methoxypropyl)urea
  • 3-Chloromercuri-2-methoxypropylurea
  • AI3-18000
  • Chlormerodrin
  • Chlormerodrine
  • Chlormerodrine [INN-French]
  • Chlormerodrinum
  • Chlormerodrinum [INN-Latin]
  • Chlormeroprin
  • Chloromerodrin
  • Clormerodrina
  • Clormerodrina [INN-Spanish]
  • Diurone
  • EINECS 200-530-4
  • EX 1347
  • Katonil
  • Mercardox
  • Mercloran
  • Mercoral
  • Merculest
  • Mercury, (3-((aminocarbonyl)amino)-2-methoxypropyl)chloro-
  • Mercury, (3-((aminocarbonyl)amino)-2-methoxypropyl-C1,O3)chloro-
  • Merilid
  • Neo-Hydrin
  • Neohydrin
  • NSC 19911
  • Oricur
  • Percapyl
  • Promeran
  • Promerane
  • Promeranum
  • UNII-99T5TWO621
  • Urea, (3-(chloromercuri)-2-methoxypropyl)-
  • Urea, (3-(chloromercurio)-2-methoxypropyl)-

Systematic Names

  • (3-(Chloromercuri)-2-methoxypropyl)urea
  • Chlormerodrin
  • Mercury, (3-((aminocarbonyl)amino)-2-methoxypropyl)chloro-
  • Mercury, (3-((aminocarbonyl)amino)-2-methoxypropyl-C1,O3)chloro- (9CI)
  • Mercury, chloro(2-methoxy-3-ureidopropyl)-

Registry Numbers

CAS Registry Number

  • 62-37-3

FDA UNII

  • 99T5TWO621

System Generated Number

  • 0000062373

Structure Descriptors

InChI

1S/C5H10N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h1,4H,3H2,2H3,(H3,6,7,8);1H;/q-1;;+2/p-1

InChIKey

RWPUPAVPTLMBLV-UHFFFAOYSA-M

Smiles

C([C@@H](C[Hg+])OC)NC(N)=O.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 215mg/kg (215mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 181, 1963.
mouse LDLo intraperitoneal 62500ug/kg (62.5mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 144, 1953.
mouse LDLo subcutaneous 60mg/kg (60mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 689, 1957.
rat LD50 oral 150mg/kg (150mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 152.5 deg C   EXP
log P (octanol-water) -0.8 (none)   EXP
Water Solubility 1.10E+04 mg/L 25 EXP
Vapor Pressure 1.66E-05 mm Hg 25 EST
Henry's Law Constant 8.83E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.44E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.