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Substance Name: Phenacetin [USP:INN:JAN]
RN: 62-44-2
UNII: ER0CTH01H9
InChIKey: CPJSUEIXXCENMM-UHFFFAOYSA-N
Note
- A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
Molecular Formula
- C10-H13-N-O2
Molecular Weight
- 179.2177
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- TSCA Flag S (Substance is Identified in a Final Significant New Use Rule)
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 2A
- Reasonably Anticipated to be a Carcinogen
- Reportable Quantity (RQ) = 100 lb
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Acetamide, N-(4-ethoxyphenyl)-
- Acetophenetidin
- N-(4-Ethoxyphenyl)acetamide
- Phenacetin
- Phenacetin [USP:INN:JAN]
MeSH Heading
- Phenacetin
Synonyms
- 1-Acetamido-4-ethoxybenzene
- 4-13-00-01092 (Beilstein Handbook Reference)
- 4-Ethoxyacetanilide
- Acet-p-phenalide
- Acetamide, N-(4-ethoxyphenyl)-
- Acetanilide, 4'-ethoxy-
- Acetic acid amide, N-(4-ethoxyphenyl)-
- Aceto-4-phenetidine
- Aceto-para-phenalide
- Aceto-para-phenetidide
- Acetophenetidin
- Acetophenetidine
- Acetophenetin
- Acetphenetidin
- Acetylphenetidin
- Achrocidin
- AI3-00783
- Anapac
- BRN 1869238
- Bromo seltzer
- Buff-A-Comp
- CCRIS 496
- Citra-fort
- Clistanol
- Codempiral
- Commotional
- Contradol
- Contradouleur
- Coricidin
- Coriforte
- Coryban-D
- Daprisal
- Dasikon
- Dasin
- Dasin CH
- Dolostop
- Edrisal
- EINECS 200-533-0
- Empiral
- Emprazil
- Emprazil-C
- Epragen
- Fenacetin
- Fenacetin [Czech]
- Fenacetina
- Fenacetina [INN-Spanish]
- Fenia
- Fenidina
- Fenina
- Fortacyl
- Gelonida
- Gewodin
- Helvagit
- Hjorton's powder
- Hocophen
- HSDB 3152
- KAFA
- Kalmin
- Malex
- Melabon
- Melaforte
- N-(4-Ethoxyphenyl)acetamide
- N-Acetyl-p-phenetidine
- N-Acetyl-para-phenetidine
- N-para-Ethoxyphenylacetamide
- NSC 7651
- p-Acetophenetide
- p-Acetophenetidide
- p-Acetophenetidine
- p-Acetphenetidin
- p-Ethoxyacetanilide
- p-Ethoxyanilid kyseliny octove
- p-Ethoxyanilid kyseliny octove [Czech]
- p-Phenetidine, N-acetyl-
- Pamprin
- para-Acetophenetidide
- para-Acetophenetidine
- para-Acetphenetidin
- para-Ethoxyacetanilide
- para-Phenacetin
- Paracetophenetidin
- Paramette
- Paratodol
- Pertonal
- Phenacet
- Phenacetin
- Phenacetine
- Phenacetine [INN-French]
- Phenacetinum
- Phenacetinum [INN-Latin]
- Phenacitin
- Phenacon
- Phenaphen
- Phenaphen plus
- Phenazetin
- Phenazetina
- Phenedina
- Phenidin
- Phenin
- Phenodyne
- Pyraphen
- Pyrroxate
- Quadronal
- RCRA waste number U187
- Robaxisal-PH
- Salgydal
- Sanalgine
- Seranex
- Sinedal
- Sinubid
- Sinutab
- Sinutabs
- Stellacyl
- Super anahist
- Synalogos
- Tacol
- Tetracydin
- Thephorin A-C
- Treupel
- UNII-ER0CTH01H9
- Veganine
- Viden
- Xaril
Systematic Names
- Acetamide, N-(4-ethoxyphenol)-
- Acetamide, N-(4-ethoxyphenyl)-
- p-Acetophenetidide
- Phenacetin
Superlist Names
- Acetamide, N-(4-ethoxyphenyl)-
- Phenacetin
- Phenacetin [Analgesic mixtures containing phenacetin]
- RCRA waste no. U187
Mixture Names
- P-A-C Compound
- Phensal
Registry Numbers
CAS Registry Number
- 62-44-2
FDA UNII
- ER0CTH01H9
System Generated Number
- 0000062442
Structure Descriptors
InChI
InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)InChIKey
CPJSUEIXXCENMM-UHFFFAOYSA-NSmiles
CCOc1ccc(NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 260mg/kg (260mg/kg) | National Technical Information Service. Vol. PB282-666, | |
guinea pig | LD50 | oral | 1870mg/kg (1870mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Toxicology and Applied Pharmacology. Vol. 2, Pg. 23, 1960. |
hamster | LD50 | oral | 1690mg/kg (1690mg/kg) | BEHAVIORAL: COMA BEHAVIORAL: ATAXIA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Pharmazie. Vol. 8, Pg. 572, 1953. |
man | LDLo | unreported | 74mg/kg (74mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
mouse | LC50 | inhalation | 33900mg/m3 (33900mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(10), Pg. 36, 1969. | |
mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 659, 1961. | |
mouse | LD50 | oral | 866mg/kg (866mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978. | |
mouse | LD50 | subcutaneous | 1625mg/kg (1625mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
rabbit | LD50 | oral | 2500mg/kg (2500mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(9), Pg. 53, 1977. | |
rabbit | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. |
rat | LD50 | intraperitoneal | 634mg/kg (634mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966. | |
rat | LD50 | oral | 1650mg/kg (1650mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 240, 1959. | |
rat | LD50 | oral | 1650mg/kg (1650mg/kg) | CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 240, 1959. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 137.5 | deg C | EXP | |
log P (octanol-water) | 1.58 | (none) | EXP | |
Water Solubility | 766 | mg/L | 25 | EXP |
Vapor Pressure | 6.92E-07 | mm Hg | 25 | EXP |
Henry's Law Constant | 2.13E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.75E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.