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Substance Name: Proadifen hydrochloride [USAN]
RN: 62-68-0
UNII: 30624AA6X2
InChIKey: FHIKZROVIDCMJA-UHFFFAOYSA-N

Note

  • An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.

Molecular Formula

  • C23-H31-N-O2.Cl-H

Molecular Weight

  • 389.964
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Synergist (Non-Specific)
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Names and Synonyms

Name of Substance

  • Proadifen hydrochloride [USAN]

Synonyms

  • 2'-Diethylaminoethyl 2,2-diphenylpentanoate hydrochloride
  • 2-(Diethylamino)ethyl-2,2-diphenylvalerate hydrochloride
  • 2-Diethylaminoethyl 2,2-diphenylvalerate hydrochloride
  • 2-Diethylaminoethyl alpha,alpha-diphenyl valerate hydrochloride
  • 5171 R. P.
  • 5171 RP
  • AI3-22677
  • Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester hydrochloride
  • beta-Diethylaminoethyl diphenylpropylacetate hydrochloride
  • Diethylaminoethanol ester of diphenylpropylacetic acid hydrochloride
  • NSC 170997
  • NSC 39690
  • Pentanoic acid, 2,2-diphenyl-, 2-(N,N-diethylamino)ethyl ester, hydrochloride
  • Proadifen HCl
  • Proadifen hydrochloride
  • Propyladiphenin
  • RP 5171
  • SK&F 525-A
  • SKF 525-A
  • SKF 525A
  • U 5446
  • UNII-30624AA6X2

Systematic Names

  • Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester, hydrochloride
  • Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester, monohydrochloride
  • Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride

Registry Numbers

CAS Registry Number

  • 62-68-0

FDA UNII

  • 30624AA6X2

Related Registry Number

  • 302-33-0 (Parent)

System Generated Number

  • 0000062680

Molecular Formulas

Molecular Formula

  • C23-H31-N-O2.Cl-H

Molecular Formula Fragments

  • C23-H31-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

InChIKey

FHIKZROVIDCMJA-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)(C(OCCN(CC)CC)=O)CCC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD intraperitoneal > 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 8, Pg. 118, 1966.
cat LD parenteral > 10mg/kg (10mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 118, 1966.
cat LDLo intravenous 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology and Applied Pharmacology. Vol. 8, Pg. 118, 1966.
mouse LD50 intraperitoneal 110mg/kg (110mg/kg)   Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969.
mouse LD50 intravenous 60mg/kg (60mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 366, 1972.
mouse LD50 oral 538mg/kg (538mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 131, 1954.
rat LD50 intraperitoneal 163mg/kg (163mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 366, 1972.
rat LD50 oral 2140mg/kg (2140mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 131, 1954.