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Substance Name: N-Nitrosodimethylamine
RN: 62-75-9
UNII: M43H21IO8R
InChIKey: UMFJAHHVKNCGLG-UHFFFAOYSA-N

Note

  • A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.

Molecular Formula

  • C2-H6-N2-O

Molecular Weight

  • 74.0824
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 199
  • 2011 CERCLA Priority List, Rank: 198
  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 1000 lb
  • TWA see 1910.1016
  • TWA: exposure by all routes should be carefully controlled to levels as low as possible; skin; Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • Dimethylnitrosamine
  • N-Nitrosodimethylamine

MeSH Heading

  • Dimethylnitrosamine

Synonyms

  • 4-04-00-03384 (Beilstein Handbook Reference)
  • AI3-25308
  • BRN 1738979
  • CCRIS 261
  • Dimethylamine, N-nitroso-
  • Dimethylnitrosamin
  • Dimethylnitrosamin [German]
  • Dimethylnitrosamine
  • Dimethylnitrosoamine
  • DMN
  • DMNA
  • EINECS 200-549-8
  • HSDB 1667
  • Methanamine, N-methyl-N-nitroso-
  • N,N-Dimethylnitrosamine
  • N-Dimethyl-nitrosamine
  • N-Methyl-N-nitrosomethanamine
  • N-Nitroaodimethylamine
  • N-Nitroso-N,N-dimethylamine
  • N-Nitrosodimethylamine
  • NDMA
  • Nitrosamine, dimethyl-
  • Nitrosodimethylamine
  • NSC 23226
  • RCRA waste number P082
  • UNII-M43H21IO8R

Systematic Names

  • Dimethylamine, N-nitroso-
  • Dimethylnitrosoamine
  • Methanamine, N-methyl-N-nitroso-
  • N,N-Dimethylnitrosamine

Superlist Names

  • Dimethylnitrosamine
  • Dimethylnitrosoamine
  • DMN
  • Methanamine, N-methyl-N-nitroso-
  • N-Nitrosodimethylamine
  • Nitrosodimethylamine
  • RCRA waste no. P082

Registry Numbers

CAS Registry Number

  • 62-75-9

FDA UNII

  • M43H21IO8R

System Generated Number

  • 0000062759

Structure Descriptors

InChI

1S/C2H6N2O/c1-4(2)3-5/h1-2H3

InChIKey

UMFJAHHVKNCGLG-UHFFFAOYSA-N

Smiles

N(N=O)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 16ppm/4H (16ppm)   AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
dog LCLo inhalation 16ppm/4H (16ppm) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
dog LDLo oral 20mg/kg (20mg/kg) BLOOD: HEMORRHAGE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS
British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
guinea pig LD50 intraperitoneal 13700ug/kg (13.7mg/kg)   Carcinogenesis Vol. 5, Pg. 533, 1984.
guinea pig LDLo oral 25mg/kg (25mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: THROMBOCYTOPENIA

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
guinea pig LDLo unreported 25mg/kg (25mg/kg) BLOOD: HEMORRHAGE British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
hamster LD50 oral 28mg/kg (28mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

LIVER: FATTY LIVER DEGERATION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Journal of the National Cancer Institute. Vol. 33, Pg. 341, 1964.
hamster LD50 subcutaneous 17700ug/kg (17.7mg/kg) LIVER: OTHER CHANGES

BLOOD: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Journal of Cancer. Vol. 33, Pg. 411, 1976.
hamster LDLo intraperitoneal 30mg/kg (30mg/kg)   Carcinogenesis Vol. 1, Pg. 91, 1980.
mammal (species unspecified) LD50 subcutaneous 10mg/kg (10mg/kg)   Acta Veterinaria Scandinavica. Vol. 22, Pg. 501, 1981.
mammal (species unspecified) LD50 subcutaneous 10mg/kg (10mg/kg) LIVER: OTHER CHANGES Acta Veterinaria Scandinavica. Vol. 22, Pg. 501, 1981.
mouse LC50 inhalation 57ppm/4H (57ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE
AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
mouse LD50 intraperitoneal 19mg/kg (19mg/kg)   Experientia. Vol. 32, Pg. 495, 1976.
mouse LDLo unreported 20mg/kg (20mg/kg) LIVER: OTHER CHANGES British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rabbit LDLo oral 10mg/kg (10mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI

LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: THROMBOCYTOPENIA
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
rabbit LDLo unreported 10mg/kg (10mg/kg) LIVER: OTHER CHANGES British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rat LC50 inhalation 78ppm/4H (78ppm) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
rat LD50 intraperitoneal 26500ug/kg (26.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: OTHER CHANGES
British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rat LD50 oral 37mg/kg (37mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(8), Pg. 81, 1985.
rat LD50 subcutaneous 15mg/kg (15mg/kg) BLOOD: THROMBOCYTOPENIA

LIVER: LIVER FUNCTION TESTS IMPAIRED

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
rat LD50 unreported 36mg/kg (36mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.
rat LDLo intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: OTHER CHANGES
British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
women LDLo oral 20mg/kg/2.5Y (20mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: NAUSEA OR VOMITING
Oncology. Vol. 37, Pg. 273, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
Boiling Point 154 deg C   EXP
log P (octanol-water) -0.57 (none)   EXP
Water Solubility 1.00E+06 mg/L 24 EXP
Vapor Pressure 2.7 mm Hg 20 EXP
Henry's Law Constant 1.82E-06 atm-m3/mole 37 EXP
Atmospheric OH Rate Constant 2.53E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.