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Substance Name: Hyoscyamine Sulfate [USP]
RN: 620-61-1
UNII: OB570Z127K
InChIKey: HOBWAPHTEJGALG-XHJLRQJWSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C17-H23-N-O3.1/2H2-O4-S

Molecular Weight

  • 676.8232
 
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Names and Synonyms

Name of Substance

  • Hyoscyamine sulfate [USP]

Synonyms

  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (alphaS)-, sulfate (2:1) (salt)
  • Egazil
  • EINECS 210-644-6
  • Hyoscyamine sulfate
  • Hyoscyamine sulfate (2:1)
  • Hyoscyamine sulfate (2:1) (salt)
  • Hyoscyamine sulfate anhydrous
  • Levsin
  • Levsin sulfate
  • Levsinex
  • Nulev
  • UNII-OB570Z127K

Systematic Names

  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (-)-tropate (ester), sulfate (2:1)
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (alphaS)-, sulfate (2:1)
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (3(S)-endo)-, sulfate (2:1) (salt)
  • Hyoscyamine sulphate

Registry Numbers

CAS Registry Number

  • 620-61-1

FDA UNII

  • OB570Z127K

Other Registry Numbers

  • 1976-91-6
  • 3715-52-4

System Generated Number

  • 0000620611

Molecular Formulas

Molecular Formula

  • C17-H23-N-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C17-H23-N-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

InChI=1S/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t2*13-,14+,15+,16-;/m11./s1

InChIKey

HOBWAPHTEJGALG-XHJLRQJWSA-N

Smiles

CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3.CN4[C@@H]5CC[C@H]4C[C@H](C5)OC(=O)[C@H](CO)c6ccccc6.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 400uL/kg/1D-I (0.4mL/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 15, Pg. 532, 1997.
infant TDLo oral 400uL/kg (0.4mL/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Emergency Medicine. Vol. 15, Pg. 532, 1997.
infant TDLo oral 800uL/kg/1D-I (0.8mL/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: IRRITABILITY

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 15, Pg. 532, 1997.
mouse LD50 intraperitoneal 210mg/kg (210mg/kg)   Journal of Pharmaceutical Sciences. Vol. 55, Pg. 849, 1966.