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Substance Name: Cyclobenzaprine hydrochloride [USAN:USP]
RN: 6202-23-9
UNII: 0VE05JYS2P
InChIKey: VXEAYBOGHINOKW-UHFFFAOYSA-N

Note

  • Lisseril is synonymous for HCl.

Molecular Formula

  • C20-H21-N.Cl-H

Molecular Weight

  • 311.8538
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Relaxant (Muscle)
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Names and Synonyms

Name of Substance

  • Cyclobenzaprine hydrochloride [USAN:USP]

Synonyms

  • 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
  • 10,11delta-Amitriptyline hydrochloride
  • 5-(3-Dimethylaminopropylidene)-5H-dibenzo-(a,d)cycloheptene hydrochloride
  • Amrix
  • Cloben
  • Cyben
  • Cyclobenzaprine HCl
  • Cyclobenzaprine hydrochloride
  • Cycloflex
  • EINECS 228-264-4
  • Flexeril
  • Flexiban
  • Lisseril
  • Miosan
  • MK 130 hydrochloride
  • Multi-Relax
  • N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine hydrochloride
  • Novo-Cycloprine
  • NSC 169900
  • NSC 173379
  • NSC 78206
  • Proheptatrien monohydrochloride
  • Proheptatriene hydrochloride
  • Proheptatriene monohydrochloride
  • Tabradol
  • Tensodox
  • TNX-102
  • TNX-102 SL
  • Tonmya
  • UNII-0VE05JYS2P
  • Yurelax

Systematic Names

  • 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
  • 3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride
  • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5)-gamma-propylamine, N,N-dimethyl-, hydrochloride
  • 5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, N,N-dimethyl-, hydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 6202-23-9

FDA UNII

  • 0VE05JYS2P

Related Registry Number

  • 303-53-7 (Parent)

System Generated Number

  • 0006202239

Molecular Formulas

Molecular Formula

  • C20-H21-N.Cl-H

Molecular Formula Fragments

  • C20-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

InChIKey

VXEAYBOGHINOKW-UHFFFAOYSA-N

Smiles

Cl.CN(C)CCC=C1c2ccccc2C=Cc3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 5714ug/kg/2D- (5.714mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: EUPHORIA
Journal of Clinical Psychiatry. Vol. 54, Pg. 39, 1993.
mouse LD50 intravenous 36mg/kg (36mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 481, 1963.
mouse LD50 oral 250mg/kg (250mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 87, 1972.
women TDLo oral 1mg/kg/3D-I (1mg/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Clinical Psychiatry. Vol. 54, Pg. 39, 1993.
women TDLo oral 8400ug/kg/2W- (8.4mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Clinical Psychiatry. Vol. 44, Pg. 151, 1983.
women TDLo oral 12mg/kg (12mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 281, 1983.