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Substance Name: Rauwolscine hydrochloride
RN: 6211-32-1
UNII: PQ323MIB24
InChIKey: PIPZGJSEDRMUAW-ZKKXXTDSSA-N

Molecular Formula

  • C21-H26-N2-O3.Cl-H

Molecular Weight

  • 390.908
 
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Names and Synonyms

Results Name

  • Rauwolscine hydrochloride

Name of Substance

  • alpha-Yohimbine hydrochloride

Synonyms

  • alpha-Yohimbin hydrochloride
  • alpha-Yohimbine hydrochloride
  • EINECS 228-279-6
  • Fauwolscine, hydrochloride
  • NSC 407307
  • Rauwolscine HCl
  • Rauwolscine hydrochloride
  • UNII-PQ323MIB24

Systematic Names

  • 20-alpha-Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester, hydrochloride
  • 20alpha-Yohimban-16beta-carboxylic acid, 17alpha-hydroxy-, methyl ester, monohydrochloride (8CI)
  • Methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16beta,17alpha,20alpha)- (9CI)

Registry Numbers

CAS Registry Number

  • 6211-32-1

FDA UNII

  • PQ323MIB24

System Generated Number

  • 0006211321

Molecular Formulas

Molecular Formula

  • C21-H26-N2-O3.Cl-H

Molecular Formula Fragments

  • C21-H26-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15+,17+,18+,19+;/m1./s1

InChIKey

PIPZGJSEDRMUAW-ZKKXXTDSSA-N

Smiles

O[C@H]1CC[C@H]2[C@@H](C[C@@H]3[N@@](C2)CCc2c4ccccc4[nH]c32)[C@@H]1C(=O)OC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 20mg/kg (20mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: GENERAL ANESTHETIC
"Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.
frog LD50 parenteral 200mg/kg (200mg/kg)   Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940.
guinea pig LD50 intraperitoneal 162mg/kg (162mg/kg)   Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940.
mouse LDLo oral 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.
rabbit LDLo intravenous 2mg/kg (2mg/kg)   "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.