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Substance Name: Montirelin
RN: 62305-91-3
InChIKey: RSHMQGIMHQPMEB-VEEXIGFHSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H24-N6-O4-S

Molecular Weight

  • 408.481
 
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Names and Synonyms

Name of Substance

  • Montirelin

Synonyms

  • Methyl(6)-oxothiomorpholinyl(5)-carbonyl-His(3)-ProNH2
  • N-((6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-prolinamide
  • PS 24

Systematic Names

  • L-Prolinamide, 6-methyl-5-oxo-3-thiomorpholinecarbonyl-L-histidyl-
  • L-Prolinamide, N-((6-methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-

Registry Numbers

CAS Registry Number

  • 62305-91-3

System Generated Number

  • 0062305913

Structure Descriptors

InChI

1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)/t9?,11-,12?,13-/m0/s1

InChIKey

RSHMQGIMHQPMEB-VEEXIGFHSA-N

Smiles

[nH]1cncc1C[C@@H](C(N1[C@H](C(N)=O)CCC1)=O)NC([C@@H]1NC([C@@H](SC1)C)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 200mg/kg (200mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Toxicological Sciences. Vol. 20(Suppl,
mouse LD50 intramuscular > 20mg/kg (20mg/kg) BEHAVIORAL: TREMOR Journal of Toxicological Sciences. Vol. 20(Suppl,
mouse LD50 intravenous > 500mg/kg (500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Journal of Toxicological Sciences. Vol. 20(Suppl,
rat LD50 intramuscular > 20mg/kg (20mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Toxicological Sciences. Vol. 20(Suppl,
rat LD50 intravenous > 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Journal of Toxicological Sciences. Vol. 20(Suppl,