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Substance Name: Methyl isocyanate
RN: 624-83-9
UNII: C588JJ4BV9
InChIKey: HAMGRBXTJNITHG-UHFFFAOYSA-N
Molecular Formula
- C2-H3-N-O
Molecular Weight
- 57.0517
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Antisickling Agents
- Hematologic Agents
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
Superlist Classification Codes
- Reportable Quantity (RQ) = 10 lb
- Threshold Planning Quantity (TPQ) = 500 lb
- TWA (0.02 ppm); skin
- TWA 0.02 ppm (0.05 mg/m3); skin
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Methyl isocyanate
Synonyms
- 4-04-00-00247 (Beilstein Handbook Reference)
- AI3-28280
- BRN 0605318
- CCRIS 1385
- EINECS 210-866-3
- HSDB 1165
- Iso-cyanatomethane
- Isocyanate de methyle
- Isocyanate de methyle [French]
- Isocyanate, methyl-
- Isocyanic acid, methyl ester
- Methane, isocyanato-
- Methyl carbonimide
- Methyl isocyanat
- Methyl isocyanat [German]
- Methyl isocyanat [German]
- Methyl isocyanate
- Methyl isocyanide
- Methylcarbylamine
- Methylisocyanaat
- Methylisocyanaat [Dutch]
- Methylisocyanate
- Methylisokyanat
- Methylisokyanat [Czech]
- Metil isocianato
- Metil isocianato [Italian]
- MIC [Isocyanate]
- NSC 64323
- RCRA waste number P064
- TL 1450
- UN 2480
- UNII-C588JJ4BV9
Systematic Names
- Isocyanic acid, methyl ester
- Methane, isocyanato-
- Methyl isocyanate
Superlist Names
- Isocyanic acid, methyl ester
- Methane, isocyanato-
- Methyl isocyanate
- Methyl isocyanate [UN2480] [Poison]
- RCRA waste no. P064
- UN2480
Registry Numbers
CAS Registry Number
- 624-83-9
FDA UNII
- C588JJ4BV9
System Generated Number
- 0000624839
Structure Descriptors
InChI
1S/C2H3NO/c1-3-2-4/h1H3InChIKey
HAMGRBXTJNITHG-UHFFFAOYSA-NSmiles
CN=C=OToxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LC50 | inhalation | 5400ppb/6H (5.4ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
human | TCLo | inhalation | 2ppm (2ppm) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Archiv fuer Toxikologie. Vol. 20, Pg. 235, 1964. |
mouse | LC50 | inhalation | 12200ppb/6H (12.2ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
mouse | LD50 | oral | 120mg/kg (120mg/kg) | Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. | |
mouse | LD50 | skin | 1820mg/kg (1820mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 391, 1987. | |
mouse | LD50 | subcutaneous | 81900ug/kg (81.9mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
rabbit | LD50 | skin | 220uL/kg (0.22mL/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | National Technical Information Service. Vol. OTS0529151, |
rabbit | LD50 | subcutaneous | 126mg/kg (126mg/kg) | Toxicology. Vol. 51, Pg. 223, 1988. | |
rat | LC50 | inhalation | 6100ppb/6H (6.1ppm) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Fundamental and Applied Toxicology. Vol. 6, Pg. 747, 1986. |
rat | LD50 | oral | 51500ug/kg (51.5mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
rat | LD50 | skin | 2780mg/kg (2780mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 391, 1987. | |
rat | LD50 | subcutaneous | 261mg/kg (261mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Indian Journal of Experimental Biology. Vol. 25, Pg. 531, 1987. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -4.50E+01 | deg C | EXP | |
Boiling Point | 39.5 | deg C | EXP | |
log P (octanol-water) | 0.790 | (none) | EST | |
Water Solubility | 2.92E+04 | mg/L | 25 | EST |
Vapor Pressure | 348 | mm Hg | 20 | EXP |
Henry's Law Constant | 9.26E-04 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.36E-13 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.