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Substance Name: Progabide [USAN:INN:BAN]
RN: 62666-20-0
UNII: 38C836J57Z
InChIKey: IBALRBWGSVJPAP-FXBPSFAMSA-N

Note

  • GABA agonist.

Molecular Formula

  • C17-H16-Cl-F-N2-O2

Molecular Weight

  • 334.776
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Anticonvulsant
  • Anticonvulsants
  • Antidepressive Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Agonists
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Relaxant (Muscle)
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Progabide
  • Progabide [USAN:INN:BAN]

Synonyms

  • 4-(((4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)butanamide
  • 4-((alpha-(p-Chlorophenyl)-5-fluorosalicylidene)amino)butyramide
  • 4-(alpha-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino)butyramide
  • BRN 2339306
  • Butanamide, 4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)-
  • Butyramide, 4-(alpha-(p-chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino)-
  • EINECS 263-679-4
  • Gabren
  • Halogabide
  • Progabida
  • Progabida [INN-Spanish]
  • Progabide
  • Progabidum
  • Progabidum [INN-Latin]
  • SL 76 002
  • SL 76-002
  • UNII-38C836J57Z

Systematic Names

  • Butanamide, 4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene)amino)-
  • Progabide

Registry Numbers

CAS Registry Number

  • 62666-20-0

FDA UNII

  • 38C836J57Z

System Generated Number

  • 0062666200

Structure Descriptors

InChI

1S/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)/b21-17-

InChIKey

IBALRBWGSVJPAP-FXBPSFAMSA-N

Smiles

C(\c1c(ccc(c1)F)O)(c1ccc(Cl)cc1)=N/CCCC(N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 900mg/kg (900mg/kg)   United States Patent Document. Vol. #4094992,
mouse LD50 oral 1350mg/kg (1350mg/kg)   L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series Vol. 3, Pg. 203, 1985.
rat LD50 oral 1350mg/kg (1350mg/kg)   L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series Vol. 3, Pg. 203, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 133-135 deg C   EXP
log P (octanol-water) 3.06 (none)   EXP
Water Solubility 70.9 mg/L 25 EST
Vapor Pressure 6.13E-11 mm Hg 25 EST
Henry's Law Constant 7.61E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.38E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.