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Substance Name: Panamidin dihydrochloride
RN: 6275-69-0
InChIKey: UCMKQLSOWSNOED-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H20-N4-O2.2Cl-H

Molecular Weight

  • 385.293
 
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Names and Synonyms

Results Name

  • Panamidin dihydrochloride

Synonyms

  • 4,4'-(Trimethylenedioxy)dibenzamidine dihydrochloride
  • 4,4'-Diamidino-1,3-diphenoxypropane dihydrochloride
  • 4,4'-Diamidino-alpha,gamma-diphenoxypropane dihydrochloride
  • Benzamidine, 4,4'-(trimethylenedioxy)di-, dihydrochloride
  • Benzenecarboximidamide, 4,4'-(1,3-propanediylbis(oxy))bis-, dihydrochloride
  • M & B 782 dihydrochloride
  • NSC 33297
  • Panamidin dihydrochloride
  • Propamide dihydrochloride
  • Propamidine dihydrochloride

Systematic Names

  • Benzamidine, 4,4'-(trimethylenedioxy)di-, dihydrochloride
  • Benzenecarboximidamide, 4,4'-(1,3-propanediylbis(oxy))bis-, dihydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 6275-69-0

Related Registry Number

  • 104-32-5 (Parent)

System Generated Number

  • 0006275690

Molecular Formulas

Molecular Formula

  • C17-H20-N4-O2.2Cl-H

Molecular Formula Fragments

  • C17-H20-N4-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H20N4O2.2ClH/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21;;/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21);2*1H

InChIKey

UCMKQLSOWSNOED-UHFFFAOYSA-N

Smiles

C(c1ccc(cc1)OCCCOc1ccc(C(=N)N)cc1)(=N)N.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Antibiotics and Chemotherapy Vol. 2, Pg. 581, 1952.
mouse LD50 intravenous 35100ug/kg (35.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics and Chemotherapy Vol. 2, Pg. 581, 1952.
mouse LD50 subcutaneous 55mg/kg (55mg/kg)   Annals of Tropical Medicine and Parasitology. Vol. 37, Pg. 1, 1943.
mouse LD50 subcutaneous 55mg/kg (55mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of Tropical Medicine and Parasitology. Vol. 37, Pg. 1, 1943.