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Substance Name: Tilisolol hydrochloride
RN: 62774-96-3
UNII: JW02T8UTIN
InChIKey: SGPGESCZOCHFCL-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H24-N2-O3.Cl-H

Molecular Weight

  • 340.849
 
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Names and Synonyms

Name of Substance

  • Tilisolol hydrochloride

Synonyms

  • (+-)-4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinolinone hydrochloride
  • CCRIS 3490
  • N 696
  • N-696
  • Tilisolol HCl
  • UNII-JW02T8UTIN

Systematic Names

  • (+-)-4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinoline hydrochloride
  • 1(2H)-Isoquinolinone, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-2-methyl-, monohydrochloride
  • 1(2H)-Isoquinolinone, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy-2-methyl-,

Registry Numbers

CAS Registry Number

  • 62774-96-3

FDA UNII

  • JW02T8UTIN

System Generated Number

  • 0062774963

Molecular Formulas

Molecular Formula

  • C17-H24-N2-O3.Cl-H

Molecular Formula Fragments

  • C17-H24-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H24N2O3.ClH/c1-17(2,3)18-9-12(20)11-22-15-10-19(4)16(21)14-8-6-5-7-13(14)15;/h5-8,10,12,18,20H,9,11H2,1-4H3;1H

InChIKey

SGPGESCZOCHFCL-UHFFFAOYSA-N

Smiles

c12c(c(n(C)cc1OC[C@@H](C[NH2+]C(C)(C)C)O)=O)cccc2.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 3369mg/kg (3369mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 505, 1987.
mouse LD50 intraperitoneal 557mg/kg (557mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
mouse LD50 intravenous 74300ug/kg (74.3mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
mouse LD50 oral 1290mg/kg (1290mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
mouse LD50 subcutaneous 1219mg/kg (1219mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
rat LD50 intraperitoneal 29mg/kg (29mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
rat LD50 intravenous 38mg/kg (38mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
rat LD50 oral 145mg/kg (145mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.
rat LD50 subcutaneous 169mg/kg (169mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 34, Pg. 499, 1987.