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Substance Name: Iproplatin [USAN:INN:BAN]
RN: 62928-11-4
UNII: 5R9F9NE9Z2
InChIKey: HFLWCXIXASXOJO-UHFFFAOYSA-L

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Cross-Linking Reagents
  • Drug / Therapeutic Agent
  • Indicators and Reagents
  • Mutation Data

Molecular Formula

  • C6-H20-Cl2-N2-O2-Pt

Molecular Weight

  • 414.1904
 
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Names and Synonyms

Name of Substance

  • Iproplatin [USAN:INN:BAN]

Synonyms

  • ab-Dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum
  • CCRIS 3650
  • CHIP
  • cis-Dichloro-trans-dihydroxybis(isopropylamine)platinum(iv)
  • cis-Dichloro-trans-dihydroxybisisopropylamine platinum (IV)
  • Diisopropylammine-trans-dihydroxymalonatoplatinum(IV)
  • EINECS 263-762-5
  • Iproplatin
  • Iproplatine
  • Iproplatine [French]
  • Iproplatino
  • Iproplatino [Spanish]
  • Iproplatinum
  • Iproplatinum [Latin]
  • JM-28
  • JM-9
  • NSC 256927
  • UNII-5R9F9NE9Z2

Systematic Names

  • Dichlorodihydroxybis(isopropylamine)platinum
  • Iproplatin
  • Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy-
  • Platinum, dichlorodihydroxybis(2-propanamine)-, (OC-6-33)

Registry Numbers

CAS Registry Number

  • 62928-11-4

FDA UNII

  • 5R9F9NE9Z2

System Generated Number

  • 0062928114

Structure Descriptors

InChI

1S/2C3H8N.2ClH.2O.Pt/c2*1-3(2)4;;;;;/h2*3-4H,1-2H3;2*1H;;;/q2*-1;;;2*-1;+6/p-2

InChIKey

HFLWCXIXASXOJO-UHFFFAOYSA-L

Smiles

CC(C)N[Pt+4](NC(C)C)([O-])([O-])([Cl-])[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 60mg/kg (60mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.
mouse LD50 intravenous 45mg/kg (45mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.
rat LD50 intraperitoneal 60mg/kg (60mg/kg)   British Journal of Cancer. Vol. 42, Pg. 668, 1980.
rat LD50 intravenous 30mg/kg (30mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.
rat LD50 subcutaneous 92mg/kg (92mg/kg)   British Journal of Cancer. Vol. 42, Pg. 668, 1980.