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Substance Name: Phenoxybenzamine hydrochloride [USP]
RN: 63-92-3
UNII: X1IEG24OHL
InChIKey: VBCPVIWPDJVHAN-UHFFFAOYSA-N

Note

  • An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Molecular Formula

  • C18-H22-Cl-N-O.Cl-H

Molecular Weight

  • 340.292
 

Classification Codes

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen
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Names and Synonyms

Name of Substance

  • Phenoxybenzamine hydrochloride [USP]

Synonyms

  • 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
  • AI3-52044
  • Bensylyt NEN
  • Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine hydrochloride
  • CCRIS 506
  • Dibenzyline
  • Dibenzyline chloride
  • Dibenzyline hydrochloride
  • EINECS 200-569-7
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
  • N-2-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine hydrochloride
  • N-2-Phenoxyisopropyl-N-benzyl-chloroethylamine hydrochloride
  • N-Benzyl-N-phenoxyisopropyl-beta-chlorethylamine hydrochloride
  • N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine hydrochloride
  • NCI-C01661
  • NSC 37448
  • Phenoxybenzamine chloride
  • Phenoxybenzamine HCl
  • Phenoxybenzamine hydrochloride
  • UNII-X1IEG24OHL

Systematic Names

  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • Phenoxybenzamine hydrochloride

Superlist Names

  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • Phenoxybenzamine hydrochloride

Registry Numbers

CAS Registry Number

  • 63-92-3

FDA UNII

  • X1IEG24OHL

Other Registry Number

  • 34238-85-2

Related Registry Number

  • 59-96-1 (Parent)

System Generated Number

  • 0000063923

Molecular Formulas

Molecular Formula

  • C18-H22-Cl-N-O.Cl-H

Molecular Formula Fragments

  • C18-H22-Cl-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChIKey

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Smiles

c1(C[N@@H+]([C@@H](COc2ccccc2)C)CCCl)ccccc1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7143ug/kg/5D- (7.143mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Annals of Internal Medicine. Vol. 107, Pg. 119, 1987.
mouse LD50 intraperitoneal 99mg/kg (99mg/kg)   Gazzetta Chimica Italiana. Vol. 92, Pg. 3, 1962.
mouse LD50 intravenous 63750ug/kg (63.75mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse LD50 oral 900mg/kg (900mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 108, Pg. 102, 1956.
mouse LD50 subcutaneous 105mg/kg (105mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 305, 1967.
rat LDLo oral 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 110, Pg. 463, 1954.