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Substance Name: Enkephalin, met(2)-pronh2(5)-
RN: 63307-63-1
InChIKey: UIRWGVLTPPSGEN-NDBXHCKUSA-N

Classification Codes

  • Analgesics
  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents

Molecular Formula

  • C30-H40-N6-O6-S

Molecular Weight

  • 612.748
 
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Names and Synonyms

Name of Substance

  • Enkephalin, met(2)-pronh2(5)-

Synonyms

  • D-Met(sup 2)pro(sup 5)-enkephalinamide
  • GYKI 14238

Systematic Names

  • L-Prolinamide, L-tyrosyl-D-methionylglycyl-L-phenylalanyl-
  • L-Tyrosyl-D-methionylglycyl-L-phenylalanyl-L-prolinamide

Registry Numbers

CAS Registry Number

  • 63307-63-1

System Generated Number

  • 0063307631

Structure Descriptors

InChI

1S/C30H40N6O6S/c1-43-15-13-23(35-28(40)22(31)16-20-9-11-21(37)12-10-20)29(41)33-18-26(38)34-24(17-19-6-3-2-4-7-19)30(42)36-14-5-8-25(36)27(32)39/h2-4,6-7,9-12,22-25,37H,5,8,13-18,31H2,1H3,(H2,32,39)(H,33,41)(H,34,38)(H,35,40)/t22-,23+,24-,25-/m0/s1

InChIKey

UIRWGVLTPPSGEN-NDBXHCKUSA-N

Smiles

N1(C([C@@H](NC(=O)CNC([C@H](NC([C@H](Cc2ccc(cc2)O)N)=O)CCSC)=O)Cc2ccccc2)=O)[C@H](C(=O)N)CCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 278mg/kg (278mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Polish Journal of Pharmacology and Pharmacy. Vol. 39, Pg. 641, 1987.
mouse LD50 subcutaneous 1700mg/kg (1700mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Polish Journal of Pharmacology and Pharmacy. Vol. 39, Pg. 641, 1987.
rat LD50 intravenous 118mg/kg (118mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Polish Journal of Pharmacology and Pharmacy. Vol. 39, Pg. 641, 1987.
rat LD50 subcutaneous 510mg/kg (510mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Polish Journal of Pharmacology and Pharmacy. Vol. 39, Pg. 641, 1987.