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Substance Name: Flutropium bromide [INN:JAN]
RN: 63516-07-4
UNII: K3V6HB0M57
InChIKey: FNUZASGZEHGWQM-XDKPLUGXSA-M

Classification Code

  • Drug / Therapeutic Agent

Molecular Formulas

  • C24-H29-Br-F-N-O3
  • C24-H29-F-N-O3.Br

Molecular Weight

  • 478.3991
 
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Names and Synonyms

Name of Substance

  • Flutropium bromide
  • Flutropium bromide [INN:JAN]

Synonyms

  • Ba 598 BR
  • Benzilic acid-N-beta-fluoroethylnortropine ester methobromide
  • Bromure de flutropium
  • Bromure de flutropium [French]
  • Bromuro de flutropio
  • Bromuro de flutropio [Spanish]
  • Flubron
  • Flutropii bromidum
  • Flutropii bromidum [Latin]
  • Flutropium bromide
  • UNII-K3V6HB0M57

Systematic Names

  • (8r)-8-(2-Fluoroethyl)-3alpha-hydroxy-1alphaH,5alphaH-tropanium bromide, benzilate
  • 1-alpha-H,5-alpha-H-Tropanium, 8-(2-fluoroethyl)-3-alpha-hydroxy-, bromide, benzilate, (8R)-

Registry Numbers

CAS Registry Number

  • 63516-07-4

FDA UNII

  • K3V6HB0M57

System Generated Number

  • 0063516074

Molecular Formulas

Molecular Formulas

  • C24-H29-Br-F-N-O3
  • C24-H29-F-N-O3.Br

Molecular Formula Fragments

  • Br
  • C24-H29-F-N-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C24H29FNO3.BrH/c1-26(15-14-25)20-12-13-21(26)17-22(16-20)29-23(27)24(28,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,20-22,28H,12-17H2,1H3;1H/q+1;/p-1/t20-,21+,22+,26?;

InChIKey

FNUZASGZEHGWQM-XDKPLUGXSA-M

Smiles

[Br-].C[N+]1(CCF)[C@H]2CC[C@@H]1CC(C2)OC(=O)C(O)(c3ccccc3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 53mg/kg (53mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
mouse LD50 intravenous 11mg/kg (11mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986.
mouse LD50 oral 760mg/kg (760mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986.
mouse LD50 subcutaneous 228mg/kg (228mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
rat LD50 intraperitoneal 77mg/kg (77mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
rat LD50 intravenous 12500ug/kg (12.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.
rat LD50 oral 740mg/kg (740mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986.
rat LD50 subcutaneous 615mg/kg (615mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.