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Substance Name: Cefazedone sodium
RN: 63521-15-3
UNII: 658X66LF6Y
InChIKey: KPHCAENKLGZHCB-VQZRABBESA-M

Classification Codes

  • Antibiotics
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formulas

  • C18-H14-Cl2-N5-O5-S3.Na
  • C18-H15-Cl2-N5-O5-S3.Na

Molecular Weight

  • 570.4326
 
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Names and Synonyms

Results Name

  • Cefazedone sodium

Name of Substance

  • Cefazedone sodium

Synonyms

  • Cefazedon natrium
  • Cefazedone sodium salt
  • EINECS 264-293-9
  • EMD 30087
  • Refosporen
  • UNII-658X66LF6Y

Systematic Names

  • 5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-(6R,7R)-7-(2-(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetamido)-, monosodium salt
  • Sodium (6R-trans)-7-(((3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl)amino)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

Registry Numbers

CAS Registry Number

  • 63521-15-3

FDA UNII

  • 658X66LF6Y

Related Registry Number

  • 56187-47-4 (Parent)

System Generated Number

  • 0063521153

Molecular Formulas

Molecular Formulas

  • C18-H14-Cl2-N5-O5-S3.Na
  • C18-H15-Cl2-N5-O5-S3.Na

Molecular Formula Fragments

  • C18-H14-Cl2-N5-O5-S3
  • C18-H15-Cl2-N5-O5-S3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C18H15Cl2N5O5S3.Na/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24;/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30);/q;+1/p-1/t12-,16-;/m1./s1

InChIKey

KPHCAENKLGZHCB-VQZRABBESA-M

Smiles

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)CN4C=C(Cl)C(=O)C(=C4)Cl)C3=O)C(=O)[O-])s1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse LD50 intramuscular > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse LD50 intravenous 6800mg/kg (6800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rabbit LD50 intravenous 3200mg/kg (3200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 intramuscular > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 intravenous 4225mg/kg (4225mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.