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Substance Name: Pazopanib hydrochloride [USAN:JAN]
RN: 635702-64-6
UNII: 33Y9ANM545
InChIKey: MQHIQUBXFFAOMK-UHFFFAOYSA-N

Note

  • NCI: The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C21-H23-N7-O2-S.Cl-H

Molecular Weight

  • 473.9866
 

Classification Codes

  • Antineoplastic Agent, a Potent and Selective Inhibitor of VEGFR-1,-2 and -3 Tyrosine Kinases, Blocking Angiogenesis
  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Pazopanib hydrochloride [USAN:JAN]

Synonyms

  • 5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochloride
  • Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, monohydrochloride
  • GW786034B
  • Pazopanib hydrochloride
  • UNII-33Y9ANM545

Registry Numbers

CAS Registry Number

  • 635702-64-6

FDA UNII

  • 33Y9ANM545

System Generated Number

  • 0635702646

Molecular Formulas

Molecular Formula

  • C21-H23-N7-O2-S.Cl-H

Molecular Formula Fragments

  • C21-H23-N7-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H

InChIKey

MQHIQUBXFFAOMK-UHFFFAOYSA-N

Smiles

Cl.CN(c1ccc2c(C)n(C)nc2c1)c3ccnc(Nc4ccc(C)c(c4)S(=O)(=O)N)n3