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Substance Name: Nilutamide [USAN:INN:BAN]
RN: 63612-50-0
UNII: 51G6I8B902
InChIKey: XWXYUMMDTVBTOU-UHFFFAOYSA-N

Classification Codes

  • Androgen Antagonists
  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect

Molecular Formula

  • C12-H10-F3-N3-O4

Molecular Weight

  • 317.222
 
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Names and Synonyms

Name of Substance

  • Nilutamide
  • Nilutamide [USAN:INN:BAN]

Synonyms

  • 1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazolidine-2,5-dione
  • 2,4-Imidazolidinedione, 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-
  • 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione
  • 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin
  • 5-24-05-00358 (Beilstein Handbook Reference)
  • Anandron
  • BRN 0841906
  • Nilandron
  • Nilandrone
  • Nilutamida
  • Nilutamida [Spanish]
  • Nilutamide
  • Nilutamidum
  • Nilutamidum [Latin]
  • NSC 758683
  • Ru 23908
  • RU 23908-10
  • RU-23908
  • UNII-51G6I8B902

Systematic Names

  • 2,4-Imidazolidinedione, 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-
  • 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin

Registry Numbers

CAS Registry Number

  • 63612-50-0

FDA UNII

  • 51G6I8B902

System Generated Number

  • 0063612500

Structure Descriptors

InChI

InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)

InChIKey

XWXYUMMDTVBTOU-UHFFFAOYSA-N

Smiles

CC1(C)NC(=O)N(C1=O)c2ccc(c(c2)C(F)(F)F)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Drugs of the Future. Vol. 12, Pg. 763, 1987.
mouse LD50 oral 200mg/kg (200mg/kg)   Drugs of the Future. Vol. 12, Pg. 763, 1987.
rat LD50 intraperitoneal 125mg/kg (125mg/kg)   Drugs of the Future. Vol. 12, Pg. 763, 1987.
rat LD50 oral 195mg/kg (195mg/kg)   Drugs of the Future. Vol. 12, Pg. 763, 1987.