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Substance Name: Betaxolol hydrochloride [USAN:USP:JAN]
RN: 63659-19-8
UNII: 6X97D2XT0O
InChIKey: CHDPSNLJFOQTRK-UHFFFAOYSA-N

Note

  • A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.

Molecular Formula

  • C18-H29-N-O3.Cl-H

Molecular Weight

  • 343.892
 

Classification Codes

  • Anti-Anginal
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Betaxolol hydrochloride [USAN:USP:JAN]

Synonyms

  • (+-)-1-(p-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol hydrochloride
  • 1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-ol hydrochloride
  • ALO 1401-02
  • Betaxolol HCl
  • Betaxolol hydrochloride
  • Betoptic
  • Betoptic S
  • Betoptima
  • EINECS 264-384-3
  • Kerlon
  • Kerlone
  • Lokren
  • SL 75 212-10
  • SL 75.212-10
  • UNII-6X97D2XT0O

Systematic Names

  • 1-(Isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol hydrochloride
  • 2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, hydrochloride, (+-)-

Mixture Name

  • Betoptic pilo

Registry Numbers

CAS Registry Number

  • 63659-19-8

FDA UNII

  • 6X97D2XT0O

Related Registry Number

  • 63659-18-7 (Parent)

System Generated Number

  • 0063659198

Molecular Formulas

Molecular Formula

  • C18-H29-N-O3.Cl-H

Molecular Formula Fragments

  • C18-H29-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChIKey

CHDPSNLJFOQTRK-UHFFFAOYSA-N

Smiles

Cl.CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 30mg/kg (30mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
mouse LD50 intravenous 37mg/kg (37mg/kg)   United States Patent Document. Vol. #4252984,
mouse LD50 oral 48mg/kg (48mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series Vol. 1, Pg. 43, 1983.
mouse LD50 subcutaneous 332mg/kg (332mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 intravenous 27400ug/kg (27.4mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 oral 998mg/kg (998mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 oral 998mg/kg (998mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 subcutaneous 389mg/kg (389mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,