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Substance Name: Nisoldipine [USAN:INN:BAN:JAN]
RN: 63675-72-9
UNII: 4I8HAB65SZ
InChIKey: VKQFCGNPDRICFG-UHFFFAOYSA-N
Note
- A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
Molecular Formula
- C20-H24-N2-O6
Molecular Weight
- 388.4176
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Vasodilator (Coronary)
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Nisoldipine
- Nisoldipine [USAN:INN:BAN:JAN]
MeSH Heading
- Nisoldipine
Synonyms
- (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
- Bay k 5552
- BRN 0454188
- EINECS 264-407-7
- Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat
- Nisocor
- Nisoldipine
- Nisoldipino
- Nisoldipino [INN-Spanish]
- Nisoldipinum
- Nisoldipinum [INN-Latin]
- NSC 759106
- Sular
- UNII-4I8HAB65SZ
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester, (+-)-
- Nisoldipine
Registry Numbers
CAS Registry Number
- 63675-72-9
FDA UNII
- 4I8HAB65SZ
System Generated Number
- 0063675729
Structure Descriptors
InChI
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 2mg/kg (2mg/kg) | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 243, 1983. | |
dog | LD50 | oral | 400mg/kg (400mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
mouse | LD50 | intravenous | 360ug/kg (0.36mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
mouse | LD50 | oral | 411mg/kg (411mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. | |
mouse | LD50 | oral | 411mg/kg (411mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
mouse | LD50 | subcutaneous | 384mg/kg (384mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
rabbit | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 243, 1983. | |
rabbit | LD50 | oral | > 5gm/kg (5000mg/kg) | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 243, 1983. | |
rat | LD50 | intravenous | 1120ug/kg (1.12mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
rat | LD50 | oral | 1257mg/kg (1257mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. | |
rat | LD50 | oral | 1257mg/kg (1257mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
rat | LD50 | subcutaneous | 674mg/kg (674mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3285, 1988. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 3.26 | (none) | EXP | |
Water Solubility | 24.6 | mg/L | 25 | EST |
Vapor Pressure | 3.04E-09 | mm Hg | 25 | EST |
Henry's Law Constant | 1.71E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.17E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.