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Substance Name: Clofibrate [USAN:USP:INN:BAN:JAN]
RN: 637-07-0
UNII: HPN91K7FU3
InChIKey: KNHUKKLJHYUCFP-UHFFFAOYSA-N

Note

  • A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)

Molecular Formula

  • C12-H15-Cl-O3

Molecular Weight

  • 242.7005
 

Classification Codes

Classification Codes

  • Anticholesteremic Agents
  • Antihyperlipidemic
  • Antimetabolites
  • Drug / Therapeutic Agent
  • Human Data
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Clofibrate
  • Clofibrate [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Clofibrate

Synonyms

  • 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
  • 4-06-00-00851 (Beilstein Handbook Reference)
  • Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester
  • alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester
  • alpha-p-Chlorophenoxyisobutyryl ethyl ester
  • Amotril
  • Amotril S
  • Angiokapsul
  • Anparton
  • Antilipid
  • Antilipide
  • Apolan
  • Arterioflexin
  • Arterosol
  • Artevil
  • Ateculon
  • Ateriosan
  • Athebrate
  • Atheromide
  • Atheropront
  • Athranid-wirkstoff
  • Atrolen
  • Atromid
  • Atromid-S
  • Atromida
  • Atromidin
  • Atrovis
  • AY 61123
  • AY-61123
  • Azionyl
  • Bioscleran
  • Bresit
  • BRN 1913459
  • Cartagyl
  • CCRIS 177
  • Chlorphenisate
  • Cinnarizin
  • Citiflus
  • Claripex
  • Claripex CPIB
  • Cloberat
  • Clobrat
  • Clobren-SF
  • Clofar
  • Clofibate
  • Clofibram
  • Clofibrat
  • Clofibrate
  • Clofibrato
  • Clofibrato [INN-Spanish]
  • Clofibrato [Spanish]
  • Clofibratum
  • Clofibratum [INN-Latin]
  • Clofinit
  • Clofipront
  • CPIB
  • Delipid
  • Deliva
  • Dura clofibrat
  • EINECS 211-277-4
  • ELPI
  • EPIB
  • Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
  • Ethyl 2-(p-chlorophenoxy)-2-methylpropionate
  • Ethyl 2-(p-chlorophenoxy)isobutyrate
  • Ethyl 2-(para-chlorophenoxy)-2-methylpropionate (IUPAC)
  • Ethyl alpha-(4-chlorophenoxy)-alpha-methylpropionate
  • Ethyl alpha-(4-chlorophenoxy)isobutyrate
  • Ethyl alpha-(p-chlorophenoxy)-alpha-methylpropionate
  • Ethyl alpha-(p-chlorophenoxy)isobutyrate
  • Ethyl chlorophenoxyisobutyrate
  • Ethyl clofibrate
  • Ethyl para-chlorophenoxyisobutyrate
  • Ethyl-alpha-p-chlorophenoxy-isobutyrate
  • Fibralem
  • Gerastop
  • HSDB 3038
  • Hyclorate
  • ICI 28257
  • Isobutyric acid, alpha-(p-chlorophenoxy)-, ethyl ester
  • Klofibrat
  • Klofiran
  • Levatrom
  • Lipamid
  • Lipavil
  • Lipavlon
  • Lipide 500
  • Lipidsenker
  • Lipofacton
  • Lipomid
  • Liponorm
  • Liporeduct
  • Liporil
  • Liposid
  • Liprin
  • Liprinal
  • Lobetrin
  • Miscleron
  • Misclerone
  • Negalip
  • neo-Atomid
  • Neo-atromid
  • Normalip
  • Normat
  • Normet
  • Normolipol
  • NSC 79389
  • NSC-79389
  • OXAN 600
  • Persantinat
  • Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
  • Propanoic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
  • Propionic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
  • Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
  • Recolip
  • Regardin
  • Regelan
  • Regelan N
  • Robigram
  • Scrobin
  • Serotinex
  • Skerolip
  • Sklero
  • Sklero-tablinen
  • Sklero-tabuls
  • Skleromexe
  • Ticlobran
  • UNII-HPN91K7FU3
  • Xyduril
  • Yoclo

Systematic Names

  • Clofibrate
  • Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
  • Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester

Superlist Name

  • Clofibrate

Registry Numbers

CAS Registry Number

  • 637-07-0

FDA UNII

  • HPN91K7FU3

System Generated Number

  • 0000637070

Structure Descriptors

InChI

InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChIKey

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Smiles

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 1280mg/kg (1280mg/kg)   Drugs of the Future. Vol. 4, Pg. 140, 1979.
hamster LD50 intraperitoneal 1260mg/kg (1260mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
hamster LD50 oral 2400mg/kg (2400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mammal (species unspecified) LD50 oral 3gm/kg (3000mg/kg)   Drugs of the Future. Vol. 4, Pg. 140, 1979.
man TDLo oral 1071ug/kg (1.071mg/kg) BEHAVIORAL: TREMOR Neurology. Vol. 37, Pg. 881, 1987.
man TDLo oral 171mg/kg/6D-I (171mg/kg) MUSCULOSKELETAL: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS		 Israel Journal of Medical Sciences. Vol. 20, Pg. 1082, 1984.
man TDLo oral 4232mg/kg/57W (4232mg/kg) MUSCULOSKELETAL: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Japanese Journal of Medicine. Vol. 29, Pg. 545, 1990.
mouse LD50 intraperitoneal 540mg/kg (540mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mouse LD50 intravenous > 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 341, 1990.
mouse LD50 oral 1220mg/kg (1220mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 32, Pg. 1568, 1984.
mouse LD50 unreported 1500mg/kg (1500mg/kg)   British UK Patent Application. Vol. #2041937,
rabbit LD50 oral 1370mg/kg (1370mg/kg)   Drugs of the Future. Vol. 4, Pg. 140, 1979.
rat LD50 intraperitoneal 910mg/kg (910mg/kg)   Journal Europeen de Toxicologie. Vol. 5, Pg. 239, 1972.
rat LD50 oral 940mg/kg (940mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Archivos de Farmacologia y Toxicologia. Vol. 6, Pg. 255, 1980.
rat LD50 unreported 1500mg/kg (1500mg/kg)   United States Patent Document. Vol. #4412998,
women TDLo oral 80mg/kg/2D-I (80mg/kg)   New England Journal of Medicine. Vol. 301, Pg. 1345, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 3.620 (none)   EST
Atmospheric OH Rate Constant 8.89E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.