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Substance Name: Clofibrate [USAN:USP:INN:BAN:JAN]
RN: 637-07-0
UNII: HPN91K7FU3
InChIKey: KNHUKKLJHYUCFP-UHFFFAOYSA-N
Note
- A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986).
Molecular Formula
- C12-H15-Cl-O3
Molecular Weight
- 242.7005
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anticholesteremic Agents
- Antihyperlipidemic
- Antimetabolites
- Drug / Therapeutic Agent
- Human Data
- Hypolipidemic Agents
- Lipid Regulating Agents
- Mutation Data
- Reproductive Effect
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms
Name of Substance
- Clofibrate
- Clofibrate [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Clofibrate
Synonyms
- 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester
- 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
- 4-06-00-00851 (Beilstein Handbook Reference)
- Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester
- alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester
- alpha-p-Chlorophenoxyisobutyryl ethyl ester
- Amotril
- Amotril S
- Angiokapsul
- Anparton
- Antilipid
- Antilipide
- Apolan
- Arterioflexin
- Arterosol
- Artevil
- Ateculon
- Ateriosan
- Athebrate
- Atheromide
- Atheropront
- Athranid-wirkstoff
- Atrolen
- Atromid
- Atromid-S
- Atromida
- Atromidin
- Atrovis
- AY 61123
- AY-61123
- Azionyl
- Bioscleran
- Bresit
- BRN 1913459
- Cartagyl
- CCRIS 177
- Chlorphenisate
- Cinnarizin
- Citiflus
- Claripex
- Claripex CPIB
- Cloberat
- Clobrat
- Clobren-SF
- Clofar
- Clofibate
- Clofibram
- Clofibrat
- Clofibrate
- Clofibrato
- Clofibrato [INN-Spanish]
- Clofibrato [Spanish]
- Clofibratum
- Clofibratum [INN-Latin]
- Clofinit
- Clofipront
- CPIB
- Delipid
- Deliva
- Dura clofibrat
- EINECS 211-277-4
- ELPI
- EPIB
- Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
- Ethyl 2-(p-chlorophenoxy)-2-methylpropionate
- Ethyl 2-(p-chlorophenoxy)isobutyrate
- Ethyl 2-(para-chlorophenoxy)-2-methylpropionate (IUPAC)
- Ethyl alpha-(4-chlorophenoxy)-alpha-methylpropionate
- Ethyl alpha-(4-chlorophenoxy)isobutyrate
- Ethyl alpha-(p-chlorophenoxy)-alpha-methylpropionate
- Ethyl alpha-(p-chlorophenoxy)isobutyrate
- Ethyl chlorophenoxyisobutyrate
- Ethyl clofibrate
- Ethyl para-chlorophenoxyisobutyrate
- Ethyl-alpha-p-chlorophenoxy-isobutyrate
- Fibralem
- Gerastop
- HSDB 3038
- Hyclorate
- ICI 28257
- Isobutyric acid, alpha-(p-chlorophenoxy)-, ethyl ester
- Klofibrat
- Klofiran
- Levatrom
- Lipamid
- Lipavil
- Lipavlon
- Lipide 500
- Lipidsenker
- Lipofacton
- Lipomid
- Liponorm
- Liporeduct
- Liporil
- Liposid
- Liprin
- Liprinal
- Lobetrin
- Miscleron
- Misclerone
- Negalip
- neo-Atomid
- Neo-atromid
- Normalip
- Normat
- Normet
- Normolipol
- NSC 79389
- NSC-79389
- OXAN 600
- Persantinat
- Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
- Propanoic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
- Propionic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
- Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
- Recolip
- Regardin
- Regelan
- Regelan N
- Robigram
- Scrobin
- Serotinex
- Skerolip
- Sklero
- Sklero-tablinen
- Sklero-tabuls
- Skleromexe
- Ticlobran
- UNII-HPN91K7FU3
- Xyduril
- Yoclo
Systematic Names
- Clofibrate
- Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
- Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
Superlist Name
- Clofibrate
Registry Numbers
CAS Registry Number
- 637-07-0
FDA UNII
- HPN91K7FU3
System Generated Number
- 0000637070
Structure Descriptors
InChI
InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3InChIKey
KNHUKKLJHYUCFP-UHFFFAOYSA-NSmiles
CCOC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 1280mg/kg (1280mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
hamster | LD50 | intraperitoneal | 1260mg/kg (1260mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
hamster | LD50 | oral | 2400mg/kg (2400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
mammal (species unspecified) | LD50 | oral | 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
man | TDLo | oral | 1071ug/kg (1.071mg/kg) | BEHAVIORAL: TREMOR | Neurology. Vol. 37, Pg. 881, 1987. |
man | TDLo | oral | 171mg/kg/6D-I (171mg/kg) | MUSCULOSKELETAL: OTHER CHANGES BEHAVIORAL: MUSCLE WEAKNESS | Israel Journal of Medical Sciences. Vol. 20, Pg. 1082, 1984. |
man | TDLo | oral | 4232mg/kg/57W (4232mg/kg) | MUSCULOSKELETAL: OTHER CHANGES BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Japanese Journal of Medicine. Vol. 29, Pg. 545, 1990. |
mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
mouse | LD50 | intravenous | > 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 341, 1990. | |
mouse | LD50 | oral | 1220mg/kg (1220mg/kg) | Chemical and Pharmaceutical Bulletin. Vol. 32, Pg. 1568, 1984. | |
mouse | LD50 | unreported | 1500mg/kg (1500mg/kg) | British UK Patent Application. Vol. #2041937, | |
rabbit | LD50 | oral | 1370mg/kg (1370mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
rat | LD50 | intraperitoneal | 910mg/kg (910mg/kg) | Journal Europeen de Toxicologie. Vol. 5, Pg. 239, 1972. | |
rat | LD50 | oral | 940mg/kg (940mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archivos de Farmacologia y Toxicologia. Vol. 6, Pg. 255, 1980. |
rat | LD50 | unreported | 1500mg/kg (1500mg/kg) | United States Patent Document. Vol. #4412998, | |
women | TDLo | oral | 80mg/kg/2D-I (80mg/kg) | New England Journal of Medicine. Vol. 301, Pg. 1345, 1979. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | < 25 | deg C | EXP | |
log P (octanol-water) | 3.620 | (none) | EST | |
Atmospheric OH Rate Constant | 8.89E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.