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Substance Name: Pramoxine hydrochloride [USP]
RN: 637-58-1
UNII: 88AYB867L5
InChIKey: SYCBXBCPLUFJID-UHFFFAOYSA-N

Classification Codes

  • Anesthetic (Topical)
  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H27-N-O3.Cl-H

Molecular Weight

  • 329.8652
 
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Names and Synonyms

Name of Substance

  • Pramoxine hydrochloride
  • Pramoxine hydrochloride [USP]

Synonyms

  • 4-(3-(p-Butoxyphenoxy)propyl)morpholine hydrochloride
  • EINECS 211-293-1
  • gamma-Morpholinopropyl 4-n-butoxyphenyl ether hydrochloride
  • HSDB 7220
  • Morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride
  • NSC 25573
  • p-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride
  • Pramoxine HCl
  • Pramoxine hydrochloride
  • Prax Lotion
  • Tronolane
  • Tronothane
  • UNII-88AYB867L5

Systematic Names

  • Morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride
  • Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride
  • Pramocaine hydrochloride

Mixture Names

  • Epifoam
  • Itch-X
  • Proctocream-HC
  • Proctofoam-HC
  • ProctoFoam-NS

Registry Numbers

CAS Registry Number

  • 637-58-1

FDA UNII

  • 88AYB867L5

Related Registry Number

  • 140-65-8 (Parent)

System Generated Number

  • 0000637581

Molecular Formulas

Molecular Formula

  • C17-H27-N-O3.Cl-H

Molecular Formula Fragments

  • C17-H27-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChIKey

SYCBXBCPLUFJID-UHFFFAOYSA-N

Smiles

N1(CCOCC1)CCCOc1ccc(cc1)OCCCC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 109mg/kg (109mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CARDIAC OUTPUT

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
mouse LD50 intraperitoneal 460mg/kg (460mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse LD50 intravenous 79500ug/kg (79.5mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.
mouse LD50 oral 1050mg/kg (1050mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse LD50 subcutaneous 1470mg/kg (1470mg/kg) CARDIAC: CARDIAC OUTPUT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
rabbit LD50 intravenous 39mg/kg (39mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.