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Substance Name: Arbaclofen hydrochloride
RN: 63701-55-3
UNII: 8703929ITD
InChIKey: WMNUVYYLMCMHLU-QRPNPIFTSA-N

Note

  • A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist at GABA-B receptors (RECEPTORS, GABA-B). It is used in the treatment of spasticity, especially that due to spinal cord damage. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Molecular Formula

  • C10-H12-Cl-N-O2.Cl-H

Molecular Weight

  • 250.1237
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Arbaclofen hydrochloride

Name of Substance

  • (R)-Baclofen monohydrochloride

Synonyms

  • (+)-Baclofen hydrochloride
  • (+)-R-3-(p-Chlorophenyl)-4-aminobutanoic acid hydrochloride
  • (R)-Baclofen monohydrochloride
  • Arbaclofen HCl
  • Arbaclofen hydrochloride
  • Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, hydrochloride, (R)-
  • d-Baclofen hydrochloride
  • UNII-8703929ITD

Systematic Name

  • Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (R)-

Registry Numbers

CAS Registry Number

  • 63701-55-3

FDA UNII

  • 8703929ITD

System Generated Number

  • 0063701553

Molecular Formulas

Molecular Formula

  • C10-H12-Cl-N-O2.Cl-H

Molecular Formula Fragments

  • C10-H12-Cl-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

InChIKey

WMNUVYYLMCMHLU-QRPNPIFTSA-N

Smiles

c1cc(ccc1[C@@H](CC(=O)O)CN)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 523mg/kg (523mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 187, 1980.