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Substance Name: Hygromycin
RN: 6379-56-2
UNII: 3YJY415DDI
InChIKey: YQYJSBFKSSDGFO-IIHALWDASA-N

Note

  • A cinnamide derivative produced by Streptomyces hygroscopicus.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C23-H29-N-O12

Molecular Weight

  • 511.4771
 
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Names and Synonyms

Name of Substance

  • Hygromycin
  • Hygromycin A

Synonyms

  • 4-(5-Acetyl-3,4-dihydroxy-2-tetrahydrofuranyloxy)-3-hydroxy-alpha-methyl-N-(2,3,6-trihydroxy-4,5-methylendioxycyclohexyl)zimtsaeureamid
  • Homomycin (6CI)
  • Hygromycin A
  • Totomycin
  • UNII-3YJY415DDI

Systematic Names

  • D-nes-Inositol, 5-deoxy-5-((3-(4-((6-deoxy-beta-D-arabino-hexofuranos-5-ulos-1-yl)oxy)-3-hydroxyphenyl)-2-methyl-1-oxo-2-propenyl)amino)-1,2-O-methylene-, (E)-
  • Hygromycin (7CI,8CI)

Registry Numbers

CAS Registry Number

  • 6379-56-2

FDA UNII

  • 3YJY415DDI

Other Registry Numbers

  • 102489-39-4
  • 11049-00-6

System Generated Number

  • 0006379562

Structure Descriptors

InChI

1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1

InChIKey

YQYJSBFKSSDGFO-IIHALWDASA-N

Smiles

C/C(=C\c1ccc(c(c1)O)O[C@H]2[C@H]([C@@H]([C@H](O2)C(=O)C)O)O)/C(=O)N[C@@H]3[C@@H]([C@H]([C@@H]4[C@H]([C@@H]3O)OCO4)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1067mg/kg (1067mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 656, 1967.
mouse LD50 intravenous 200mg/kg (200mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 332, 1981.