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Substance Name: Meclofenamate sodium [USAN:USP]
RN: 6385-02-0
UNII: 9MMQ0YER4E
InChIKey: OGPIIGMUPMPMNT-UHFFFAOYSA-M

Note

  • A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Molecular Formulas

  • C14-H10-Cl2-N-Na-O2.H2-O
  • C14-H10-Cl2-N-O2.Na
  • C14-H11-Cl2-N-O2.Na

Molecular Weight

  • 318.134
 

Classification Codes

  • Anti-Inflammatory
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Meclofenamate sodium [USAN:USP]

MeSH Heading

  • Meclofenamic acid

Synonyms

  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt
  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate
  • CI 583
  • Cl-583.Na salt
  • EINECS 228-983-3
  • INF 4668
  • Meclodium
  • Meclofenamate sodium
  • Meclomen
  • Meclonax
  • Monosodium N-(2,6-dichloro-m-tolyl)anthranilate
  • Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate
  • Movens
  • N-(2,6-Dichloro-m-tolyl)anthranilic acid sodium salt
  • Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate
  • Sodium meclofenamate
  • Sodium meclophenamate
  • UNII-9MMQ0YER4E

Systematic Names

  • Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, monosodium salt
  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt
  • Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate

Registry Numbers

CAS Registry Number

  • 6385-02-0

FDA UNII

  • 9MMQ0YER4E

System Generated Number

  • 0006385020

Molecular Formulas

Molecular Formulas

  • C14-H10-Cl2-N-Na-O2.H2-O
  • C14-H10-Cl2-N-O2.Na
  • C14-H11-Cl2-N-O2.Na

Molecular Formula Fragments

  • C14-H10-Cl2-N-Na-O2
  • C14-H10-Cl2-N-O2
  • C14-H11-Cl2-N-O2
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1

InChIKey

OGPIIGMUPMPMNT-UHFFFAOYSA-M

Smiles

c1(Nc2c(cccc2)C(=O)[O-])c(c(ccc1Cl)C)Cl.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 120mg/kg/6W (120mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983.
man TDLo oral 521mg/kg/78W- (521mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" American Journal of Gastroenterology. Vol. 82, Pg. 1320, 1987.
women TDLo oral 3mg/kg (3mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Journal of Rheumatology. Vol. 10, Pg. 169, 1983.