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Substance Name: Tozasertib [USAN:INN]
RN: 639089-54-6
UNII: 234335M86K
InChIKey: GCIKSSRWRFVXBI-UHFFFAOYSA-N

Note

  • A potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth.

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents

Molecular Formula

  • C23-H28-N8-O-S

Molecular Weight

  • 464.5952
 
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Names and Synonyms

Name of Substance

  • Tozasertib [USAN:INN]
  • VX680

Synonyms

  • Cyclopropane carboxylic acid(4-(4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl)phenyl)amide
  • Cyclopropanecarboxylic acid N-(4-((4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl)sulfanyl)phenyl)amide
  • L-001281814
  • MK 0457
  • MK-0457
  • N-(4-((4-(4-Methylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide
  • Tozasertib
  • UNII-234335M86K
  • VE 465
  • VE-465
  • VX 680
  • VX-680

Systematic Name

  • Cyclopropanecarboxamide, N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)-

Registry Numbers

CAS Registry Number

  • 639089-54-6

FDA UNII

  • 234335M86K

System Generated Number

  • 0639089546

Structure Descriptors

InChI

InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChIKey

GCIKSSRWRFVXBI-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)c2cc(Nc3cc(C)[nH]n3)nc(Sc4ccc(NC(=O)C5CC5)cc4)n2