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Substance Name: Lobeline hydrochloride
RN: 63990-84-1
InChIKey: MKMYPTLXLWOUSO-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H27-N-O2.Cl-H

Molecular Weight

  • 373.921
 
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Names and Synonyms

Name of Substance

  • Lobeline hydrochloride

Synonyms

  • 2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride
  • HSDB 3555
  • Lobeline HCl
  • Zoolobelin

Systematic Names

  • Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride
  • Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 63990-84-1

System Generated Number

  • 0063990841

Molecular Formulas

Molecular Formula

  • C22-H27-N-O2.Cl-H

Molecular Formula Fragments

  • C22-H27-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H

InChIKey

MKMYPTLXLWOUSO-UHFFFAOYSA-N

Smiles

C([C@@H]1[N@@]([C@@H](CC(c2ccccc2)=O)CCC1)C)[C@@H](c1ccccc1)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 30mg/kg (30mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 167, Pg. 273, 1967.
mouse LD50 intravenous 6mg/kg (6mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 167, Pg. 273, 1967.
mouse LD50 subcutaneous 37mg/kg (37mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.