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Substance Name: Morphine sulfate
RN: 64-31-3
UNII: DY70C97N30
InChIKey: USAHOPJHPJHUNS-IFCNUISUSA-N
Note
- The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Molecular Formula
- C17-H19-N-O3.1/2H2-O4-S
Molecular Weight
- 668.76
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic (Narcotic)
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Results Name
- Morphine sulfate
Name of Substance
- Morphine sulfate (anhydrous)
Synonyms
- Arymo ER
- Astramorph
- Astramorph PF
- Avinza
- Duramorph
- Duramorph PF
- EINECS 200-582-8
- Infumorph
- Kadian
- Kapanol
- l-Morphine sulfate
- Morphabond
- MorphaBond ER
- Morphine sulfate
- Morphine sulphate
- Morphine, hemisulfate
- MS Contin
- MST
- MST-1 Continus
- NIH 0001
- NIH 10753
- NSC 11441
- Oramorph SR
- Skenan
- UNII-DY70C97N30
Systematic Names
- Morphinan-3,6-alpha-diol, 7,8-didehydro-4, 5-alpha-epoxy-17-methyl-, sulfate
- Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, sulfate (2:1) (salt)
- Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, sulfate (2:1) (salt)
- Morphine sulphate
Mixture Name
- Embeda
Registry Numbers
CAS Registry Number
- 64-31-3
FDA UNII
- DY70C97N30
Other Registry Numbers
- 1095-53-0
- 178935-96-1
Related Registry Number
- 57-27-2 (Parent)
System Generated Number
- 0000064313
Molecular Formulas
Molecular Formula
- C17-H19-N-O3.1/2H2-O4-S
Molecular Formula Fragments
- C17-H19-N-O3
- COMPONENT
- H2-O4-S
Structure Descriptors
InChI
InChI=1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1InChIKey
USAHOPJHPJHUNS-IFCNUISUSA-NSmiles
CN1CC[C@]23[C@H]4Oc5c(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intravenous | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
dog | LD50 | intravenous | 316mg/kg (316mg/kg) | BEHAVIORAL: SLEEP BEHAVIORAL: ANALGESIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
duck | LD50 | intravenous | 213mg/kg (213mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
frog | LD50 | parenteral | 678mg/kg (678mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
frog | LD50 | subcutaneous | 677mg/kg (677mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948. | |
guinea pig | LD50 | subcutaneous | 391mg/kg (391mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948. | |
guinea pig | LDLo | intramuscular | 400mg/kg (400mg/kg) | JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914. | |
guinea pig | LDLo | oral | 1gm/kg (1000mg/kg) | JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914. | |
hamster | LD50 | subcutaneous | 1250mg/kg (1250mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 54, Pg. 339, 1943. | |
man | TDLo | oral | 12mg/kg/4W-I (12mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 397, 1988. |
mouse | LD50 | intracrebral | 5100ug/kg (5.1mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 155, 1963. |
mouse | LD50 | intramuscular | 334mg/kg (334mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971. |
mouse | LD50 | intraperitoneal | 275mg/kg (275mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Medicinal Chemistry. Vol. 10, Pg. 627, 1967. |
mouse | LD50 | intravenous | 156mg/kg (156mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 157, Pg. 185, 1967. |
mouse | LD50 | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961. |
mouse | LD50 | subcutaneous | 180mg/kg (180mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Australian Veterinary Journal. Vol. 49, Pg. 525, 1973. |
pigeon | LD50 | intravenous | 321mg/kg (321mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
rat | LD50 | intramuscular | 78mg/kg (78mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971. |
rat | LD50 | intraperitoneal | 235mg/kg (235mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 241, 1965. |
rat | LD50 | intravenous | 70mg/kg (70mg/kg) | Toxicology and Applied Pharmacology. Vol. 17, Pg. 250, 1970. | |
rat | LD50 | oral | 461mg/kg (461mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967. | |
rat | LD50 | subcutaneous | 108mg/kg (108mg/kg) | ENDOCRINE: OTHER CHANGES | British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 260, 1955. |
women | TDLo | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: ANALGESIA | Lancet. Vol. 1, Pg. 573, 1987. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 250 | deg C | EXP | |
log P (octanol-water) | 0.720 | (none) | EST | |
Water Solubility | 6.45E+04 | mg/L | 25 | EXP |
Vapor Pressure | 1.69E-09 | mm Hg | 25 | EST |
Henry's Law Constant | 1.33E-16 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.65E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.