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Substance Name: Morphine sulfate
RN: 64-31-3
UNII: DY70C97N30
InChIKey: USAHOPJHPJHUNS-IFCNUISUSA-N

Note

  • The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Molecular Formula

  • C17-H19-N-O3.1/2H2-O4-S

Molecular Weight

  • 668.76
 

Classification Codes

  • Analgesic (Narcotic)
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Morphine sulfate

Name of Substance

  • Morphine sulfate (anhydrous)

Synonyms

  • Arymo ER
  • Astramorph
  • Astramorph PF
  • Avinza
  • Duramorph
  • Duramorph PF
  • EINECS 200-582-8
  • Infumorph
  • Kadian
  • Kapanol
  • l-Morphine sulfate
  • Morphabond
  • MorphaBond ER
  • Morphine sulfate
  • Morphine sulphate
  • Morphine, hemisulfate
  • MS Contin
  • MST
  • MST-1 Continus
  • NIH 0001
  • NIH 10753
  • NSC 11441
  • Oramorph SR
  • Skenan
  • UNII-DY70C97N30

Systematic Names

  • Morphinan-3,6-alpha-diol, 7,8-didehydro-4, 5-alpha-epoxy-17-methyl-, sulfate
  • Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, sulfate (2:1) (salt)
  • Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, sulfate (2:1) (salt)
  • Morphine sulphate

Mixture Name

  • Embeda

Registry Numbers

CAS Registry Number

  • 64-31-3

FDA UNII

  • DY70C97N30

Other Registry Numbers

  • 1095-53-0
  • 178935-96-1

Related Registry Number

  • 57-27-2 (Parent)

System Generated Number

  • 0000064313

Molecular Formulas

Molecular Formula

  • C17-H19-N-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C17-H19-N-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1

InChIKey

USAHOPJHPJHUNS-IFCNUISUSA-N

Smiles

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35.CN6CC[C@]78[C@H]9Oc%10c(O)ccc(C[C@@H]6[C@@H]7C=C[C@@H]9O)c8%10.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
dog LD50 intravenous 316mg/kg (316mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
duck LD50 intravenous 213mg/kg (213mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
frog LD50 parenteral 678mg/kg (678mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
frog LD50 subcutaneous 677mg/kg (677mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948.
guinea pig LD50 subcutaneous 391mg/kg (391mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948.
guinea pig LDLo intramuscular 400mg/kg (400mg/kg)   JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914.
guinea pig LDLo oral 1gm/kg (1000mg/kg)   JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914.
hamster LD50 subcutaneous 1250mg/kg (1250mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 54, Pg. 339, 1943.
man TDLo oral 12mg/kg/4W-I (12mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 397, 1988.
mouse LD50 intracrebral 5100ug/kg (5.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 155, 1963.
mouse LD50 intramuscular 334mg/kg (334mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971.
mouse LD50 intraperitoneal 275mg/kg (275mg/kg) BEHAVIORAL: ANALGESIA Journal of Medicinal Chemistry. Vol. 10, Pg. 627, 1967.
mouse LD50 intravenous 156mg/kg (156mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 157, Pg. 185, 1967.
mouse LD50 oral 600mg/kg (600mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
mouse LD50 subcutaneous 180mg/kg (180mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Australian Veterinary Journal. Vol. 49, Pg. 525, 1973.
pigeon LD50 intravenous 321mg/kg (321mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
rat LD50 intramuscular 78mg/kg (78mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971.
rat LD50 intraperitoneal 235mg/kg (235mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 241, 1965.
rat LD50 intravenous 70mg/kg (70mg/kg)   Toxicology and Applied Pharmacology. Vol. 17, Pg. 250, 1970.
rat LD50 oral 461mg/kg (461mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
rat LD50 subcutaneous 108mg/kg (108mg/kg) ENDOCRINE: OTHER CHANGES British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 260, 1955.
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: ANALGESIA Lancet. Vol. 1, Pg. 573, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 250 deg C   EXP
log P (octanol-water) 0.720 (none)   EST
Water Solubility 6.45E+04 mg/L 25 EXP
Vapor Pressure 1.69E-09 mm Hg 25 EST
Henry's Law Constant 1.33E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.65E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.