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Substance Name: Paroxetine maleate
RN: 64006-44-6
UNII: F726G2563Q
InChIKey: AEIUZSKXSWGSRU-QXGDPHCHSA-N

Note

  • A serotonin uptake inhibitor that is effective in the treatment of depression.

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C19-H20-F-N-O3.x-C4-H4-O4

Molecular Weight

  • 445.441
 
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Names and Synonyms

Results Name

  • Paroxetine maleate

Name of Substance

  • Paroxetine maleate

Synonyms

  • (-)-alpha-4-(4-Fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethyl piperidine maleate
  • FG 7051 maleate
  • GF 74
  • Paroxetine maleate
  • trans-(-)-3-((1,3-Benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine maleate
  • UNII-F726G2563Q

Systematic Name

  • Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, trans-(-)-, (Z)-2-butenedioate

Registry Numbers

CAS Registry Number

  • 64006-44-6

FDA UNII

  • F726G2563Q

Related Registry Number

  • 61869-08-7 (Parent)

System Generated Number

  • 0064006446

Molecular Formulas

Molecular Formula

  • C19-H20-F-N-O3.x-C4-H4-O4

Molecular Formula Fragments

  • C19-H20-F-N-O3
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1

InChIKey

AEIUZSKXSWGSRU-QXGDPHCHSA-N

Smiles

c1([C@H]2[C@H](COc3cc4c(OCO4)cc3)CNCC2)ccc(cc1)F.OC(\C=C/C(O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 6700ug/kg (6.7mg/kg) BEHAVIORAL: EXCITEMENT American Journal of Emergency Medicine. Vol. 11, Pg. 682, 1993.
mouse LD50 oral 500mg/kg (500mg/kg)   United States Patent Document. Vol. #4007196,
mouse LD50 subcutaneous 845mg/kg (845mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1114, 1989.